岑瑶,博士,南京医科大学药学院副教授,硕士研究生导师。江苏省高校“青蓝工程”优秀青年骨干教师,南京医科大学优秀青年骨干教师。2016年博士毕业于湖南大学化学生物传感与计量学国家重点实验室分析化学专业。主要从事肿瘤与神经疾病早期诊断标志物检测新方法建立与治疗应用的研究。主持国家自然科学基金、江苏省自然科学基金等多项科研项目。以第一作者与通讯作者在国际知名期刊Analytical Chemistry、Biosensors and Bioelectronics、Nanoscale、Sensors and Actuators B: Chemical等发表论文多篇;以第一发明人授权专利2项。
研究方向:肿瘤与神经疾病早期诊断标志物检测新方法的建立与治疗应用
招生方向:药学
联系方式:E-mail: yaocen@njmu.edu.cn
教育背景及工作经历:
(1)2021/11-至今,南京医科大学,药学院药物分析学系,副教授;
(2)2019/09-2020/03,香港科技大学,化学系,访问学者;
(3)2016/09-2021/10,南京医科大学,药学院药物分析学系,讲师;
(4)2011/09-2016/06,湖南大学,化学生物传感与计量学国家重点实验室,分析化学专业,硕博连读,博士。
承担科研项目:
(1)国家自然科学基金青年基金项目,21705080,2018/01-2020/12,25万元,主持;
(2)江苏省基础研究计划(自然科学基金)青年基金项目,BK20171043,2017/07-2020/06,20万元,主持;
(3)江苏省高校自然科学研究面上项目,17KJB150029,2017/09-2019/08,3万元,主持;
(4)南京医科大学引进人才科研启动基金,2016RC04,2016/11-2021/12,10万元,主持;
(5)化学生物传感与计量学国家重点实验室(湖南大学)开放课题,2021001,2022/04-2024/04,3万元,主持;
(6)东南大学-南京医科大学合作研究项目,2017DN17,2017/07-2019/06,4万元,主持;
(7)南京医科大学科技发展基金重点项目,2016NJMUZD015,2017/01-2018/12,4万元,主持
近五年代表性论文及专利:
(1) Xia Cheng, Dandan Ren, Guanhong Xu, Fangdi Wei, Jing Yang, Jian Xu, Lin Wang, Qin Hu,* Yao Cen*. Metal-organic frameworks-assisted nonenzymatic cascade amplification multiplexed strategy for sensing acute myocardial infarction related microRNAs. Biosensors and Bioelectronics, 2022, 196, 113706.
(2) Sihan Rong, Qiutong Chen, Guanhong Xu, Fangdi Wei, Jing Yang, Dandan Ren, Xia Cheng, Xinyi Xia, Jiawei Li, Mingcong Gao, Qin Hu*, Yao Cen*. Novel and facile synthesis of heparin sulfur quantum dots via oxygen acceleration for ratiometric sensing of uric acid in human serum. Sensors and Actuators B: Chemical,2022, 353, 131146.
(3) Jian Bao, Jie Mei, Xia Cheng, Dandan Ren, Guanhong Xu, Fangdi Wei, Yong Sun, Qin Hu*, Yao Cen*. A ratiometric lanthanide-free fluorescent probe based on two-dimensional metal-organic frameworks and carbon dots for the determination of anthrax biomarker. Microchimica Acta, 2021, 188(3), 84.
(4) Jie Mei, Jian Bao, Xia Cheng, Dandan Ren, Guanhong Xu, Fangdi Wei, Yong Sun, Qin Hu*, Yao Cen*.Novel dual-emissive fluorescent silicon nanoparticles for detection of enzyme activity in supplements associated with lactose intolerance. Sensors and Actuators B: Chemical, 2021, 329, 129164.
(5) Dandan Ren, Jie Mei, Jian Bao, Fangdi Wei, Guanhong Xu, Jing Yang, Yong Sun, Qin Hu*, Yao Cen*. A novel profuse color card for convenient visual determination of iodide in human urine based on catalytic oxidation reaction. Journal of Pharmaceutical and Biomedical Analysis, 2020, 191, 113580.
(6) Yuying Chai, Xia Cheng, Guanhong Xu, Fangdi Wei, Jian Bao, Jie Mei, Dandan Ren, Qin Hu*, Yao Cen*. A nanoplatform based on metal–organic frameworks and coupled exonuclease reaction for the fluorimetric determination of T4 polynucleotide kinase activity and inhibition. Microchimica Acta, 2020, 187, 243.
(7) Xia Cheng, Yuying Chai, Jian Xu, Lin Wang, Fangdi Wei, Guanhong Xu, Yong Sun, Qin Hu*, Yao Cen*. Enzyme cascade reaction-based ratiometric fluorescence probe for visual monitoring the activity of alkaline phosphatase. Sensors and Actuators B: Chemical, 2020,309, 127765.
(8) Xia Cheng, Jian Xu, Lin Wang, Guanhong Xu, Fangdi Wei, Yuying Chai, Qin Hu*, Yao Cen*.A redox modulated ratiometric fluorometric method based on the use of dual-color carbon dots for determination of the activity of enzymes participating in ascorbic acid-related reactions. Microchimica Acta, 2019, 186(12), 818.
(9) Xiaoman Xu‡, Dandan Ren‡, Yuying Chai, Xia Cheng, Jie Mei, Jian Bao, Fangdi Wei, Guanhong Xu, Qin Hu*, Yao Cen*. Dual-emission carbon dots-based fluorescent probe for ratiometric sensing of Fe(III) and pyrophosphate in biological samples. Sensors and Actuators B: Chemical, 2019, 298, 126829.
(8) Xiaoman Xu‡, Yao Cen‡,*, Guanhong Xu, Fangdi Wei, Menglan Shi, Qin Hu*. A ratiometric fluorescence probe based on carbon dots for discriminative and highly sensitive detection of acetylcholinesterase and butyrylcholinesterase in human whole blood. Biosensors and Bioelectronics, 2019, 131, 232-236.
(9) Yao Cen, Wen-Jing Deng, Ru-Qin Yu, Xia Chu*. Sensitive fluorescence sensing of T4 polynucleotide kinase activity and inhibition based on DNA/polydopamine nanospheres platform. Talanta, 2018, 180, 271-276.
(10)Yao Cen, Wen-Jing Deng, Yuan Yang, Ru-Qin Yu, Xia Chu*. Core-shell-shell multifunctional nanoplatform for intracellular tumor-related mRNAs imaging and near-infrared light triggered photodynamic-photothermal synergistic therapy. Analytical Chemistry, 2017, 89(19), 10321-10328.
(11) 岑瑶,胡琴,徐晓曼,许贯虹,魏芳弟. 一种用于定量检测血液中AChE和BChE的比率型荧光探针的制备方法. 中国. ZL201811101596.9
(12) 岑瑶,胡琴,徐晓曼,许贯虹,魏芳弟. 一种用于定量检测尿液中PPi含量的比率型荧光探针的制备方法. 中国. ZL201811491351.1