周学敏，教授，博导，国家自然科学基金评审专家，江苏省新药评审专家。作为课题负责人获得国家各类新药证书和生产批件20余项。曾获得江苏省科技进步三等奖(1/6);南京市第二届城镇妇女科技创造发明成果二等奖(1/1);南京市科技进步三等奖(1/5)；江苏省教育教学与研究成果三等奖(1/5)。主持国家自然科学基金项目5项；参加科技部“重大新药创制”专项化药1.1类新药研究2项。在Angew. Chem.，Analytical Chemistry，BiosensBioelectron.，ACS Appl. Mater. Interfaces等发表SCI论文50余篇，累计最新IF 235，总被引1215篇次，通讯作者论文最高IF大于12，IF大于5的26篇，其中2篇进入ESI学科前2%。为Analytical Chemistry、BiosensBioelectron.、ACS Appl. Mater. Interfaces、Anal. Chim.Acta等期刊审稿人。获得授权中国发明专利22项。
研究方向：
1. 复杂体系中高灵敏和高选择性微痕量物质信息捕获新技术与新纳米元件研究及应用
2. 纳米可控自组装分子靶向化学与生物传感体系构建及应用
3. 药物质量控制及药代动力学研究
近年在研与完成课题情况：
[1] 国家自然科学基金项目“基于DNA-银纳米簇新型分子信标的荧光传感系统及医学应用”(81773681, 2018.1-2021.12)；课题负责人
[2] 国家自然科学基金项目“基于磁性分子印记聚合物的磁控电化学传感膜及临床标志物分析”(81572081, 2016.1-2019.12)；课题负责人
[3] 国家自然科学基金项目“基于还原氧化石墨烯和金属纳米粒层层自组装的分子印记电化学传感体系及临床应用”(81273480, 2013.1-2016.12)；课题负责人
[4] 国家自然科学基金项目“功能纳米硅胶表面高效率分子印记可控自组装体系构建及应用研究”(21175070, 2012.1- 2015.12)；课题负责人
[5] 国家自然科学基金项目“基于纳米硅胶表面分子印迹的固相微萃取技术用于雌激素残留分析的研究”(20875048, 2009. 1-2011.12)；课题负责人
近年以通讯作者发表的主要SCI论文：
[1] Wanying Zhu, ChaoyiGu, Johan Dunevall, Lin Ren, Xuemin Zhou*, Andrew G. Ewing*.Combined Amperometry and Electrochemical Cytometry RevealDifferential Effects of Cocaine and Methylphenidate on Exocytosis andthe Fraction of Chemical Release. Angew.Chem. Int. Ed. 58:4238 –4242, 2019.
[2] Bingzhi Li, Yue Chen, Jing Wang, Qiaoyun Lu, Wanying Zhu , Jieping Luo,Junli Hong, Xuemin Zhou*. Detecting transcription factors with allosteric DNA-Silver nanoclusterswitches.AnalyticaChimicaActa, 1048:168-177, 2019.
[3] Chunhong Zhu, Wanying Zhu, Lei Xu, Xuemin Zhou*.A label-free electrochemical aptasensor based on magneticbiocomposites with Pb2þ-dependent DNAzyme for the detection ofthrombin. AnalyticaChimicaActa,1047:21-27, 2019.
[4] Xiaoxu Li, Bingzhi Li, Junli Hong*, Xuemin Zhou*.Highly selective determination of acid phosphatase in biological samples using a biomimetic recognition-based SERS sensor.Sensors & Actuators: B. Chemical, 276:421–428,2018.
[5] Jieping Luo. Xin Shen. Bingzhi Li. Xiaoyun Li. Xuemin Zhou*.Signal amplification by strand displacement in a carbon dot based fluorometric assay for ATP. MicrochimicaActa,185:392,2018.
[6] Bingzhi Li, Yue Chen, Jing Wang, Qiaoyun Lu, Wanying Zhu, Lei Xu, Xin Shen,Jieping Luo, Chunhong Zhu, Xiaoxu Li, Junli Hong, Xuemin Zhou*. DNA-silver nanoclusters/polypyrrole nanoparticles: A label-free and enzyme-free platform for multiplexed transcription factors detection. Sensors & Actuators: B. Chemical, 274:481–490,2018.
[7] Zhu Wanying; Shen Xin; Zhu Chunhong; Li Bingzhi; Hong Junli*; Zhou Xuemin*, Turn-on fluorescent assay based on purification system via magnetic separation for highly sensitive probing of adenosine, Sensors and Actuators B: Chemical, 259:855–861, 2018.
[8] Li Bingzhi; Xu Lei; Chen Yue; Zhu Wanying; Shen Xin; Zhu Chunhong; Luo Jieping; Li Xiaoxu; Hong Junli; Zhou Xuemin*, Sensitive and Label-Free Fluorescent Detection of Transcription Factors Based on DNA-Ag Nanoclusters Molecular Beacons and Exonuclease III-Assisted Signal Amplification, Analytical Chemistry, 89:7316-7323, 2017.
[9] Xu Lei; Shen Xin; Li Bingzhi; Zhu Chunhong;Zhou Xuemin*. G-quadruplex based Exo III-assisted signal amplification aptasensor for the colorimetric detection of adenosine, AnalyticaChimicaActa, 980:58-64, 2017.
[10] Shen Xin; Xu Lei; Zhu Wanying; Li Bingzhi; Hong Junli*;Zhou Xuemin*, A turn-on fluorescence aptasensor based on carbon dots for sensitive detection of adenosine, New Journal of Chemistry, 41:9230, 2017.
[11] Jiang Guoyi; Zhu Wanying; Shen Xin; Xu Lei; Li Xiaoxu; Wang Rui; Liu Chunyu; Zhou Xuemin*, Colorimetric and visual determination of adenosine triphosphate using a boronic acid as the recognition element, and based on the deaggregation of gold nanoparticles, MicrochimicaActa, 184:4305-4312, 2017.
[12] Luo Jieping; Chen Ning; Yang Zaiyue; Han Jiyong; Zhu Wanying; Hong Junli*;Zhou Xuemin*, Determination of active ingredients in Chinese medicine Danning Tablets using dispersion solid phase extraction by molecular imprinting nanomaterials coupled with HPLC-DAD, Analytical Methods, 9:2585, 2017.
[13] Zhu Wanying; Xu Lei; Zhu Chunhong; Li Bengzhi; Xiao Hong; Jiang Huijun; Zhou Xuemin*. Magnetically controlled electrochemical sensing membrane based on multifunctional molecularly imprinted polymers for detection of insulin, ElectrochimicaActa, 218:91-100, 2016.
[14] CaiQizhi; Yang Zaiyue; Chen Ning; Zhou Xuemin*; Hong Junli*, Selective capture and rapid identification of Panaxnotoginseng metabolites in rat faeces by the integration of magnetic molecularly imprinted polymers and high-performance liquid chromatography coupled with orbitrap mass spectrometry, Journal of Chromatography A, 1455:65-73,2016.
[15] Han Qing; Shen Xin; Zhu Wanying; Zhu Chunhong;Zhou Xuemin*; Jiang Huijun*, Magnetic sensing film based on Fe3O4@Au-GSH molecularly imprinted polymers for the electrochemical detection of estradiol, BiosensBioelectron, 79:180-186, 2016.
[16] Li Bingzhi; Wang Xi; Shen Xin; Zhu Wanying; Xu Lei; Zhou Xuemin*. Aggregation-induced emission from gold nanoclusters for use as aluminescence-enhanced nanosensor to detect trace amounts of silverions, Journal of Colloid and Interface Science, 467:90–96, 2016
[17] Zaiyue Yang, QizhiCai, Ning Chen, Zhou Xuemin* and Junli Hong*, Selective separation and identification of metabolite groups of Polygonumcuspidatum extract in rat plasma using dispersion solid-phase extraction by magnetic molecularly imprinted polymers coupled with LC/Q-TOF-MS, RSC Adv, 6:12193–12204, 2016.
[18] Xiaoxu Li, Xiaoliang Mei, Lei Xu, Xin Shen, Wanying Zhu, Junli Hong, Zhou Xuemin*, Development and application of novel clonazepam molecularly imprinted coatings for stir bar sorptive extraction, Journal of Colloid and Interface Science, 468:183–191, 2016.
[19] Xi Wang, Xin Shen, Bingzhi Li, Guoyi Jiang, Zhou Xuemin*and Huijun Jiang*, One-step facile synthesis of novel b-amino alcohol functionalized carbon dots for the fabrication of a selective copper ion sensing interface based on the biuret reaction, RSC Adv, 6:18326–18332, 2016
[20] Zhu Wanying; Jiang Guoyi; Xu Lei; Li Bingzhi; CaiQizhi; Jiang Huijun; Zhou Xuemin*. Facile and controllable one-step fabrication of molecularly imprinted polymer membrane by magnetic field directed self-assembly for electrochemical sensing of glutathione, Anal. Chim.Acta, 886:37-47, 2015.
[21] Wang Xi; Chen Ning; Han Qing; Yang Zaiyue; Wu Jinhua; Xue Cheng; Hong Junli;Zhou Xuemin*; Jiang Huijun, Selective separation and determination of the synthetic colorants in beverages by magnetic solid-phase dispersion extraction based on a Fe3O4/reduced graphene oxide nanocomposite followed by high-performance liquid chromatography with diode array detection, J Sep. Sci, 38(12):2167-2173, 2015.
[22] Wu Jinhua; Yang Zaiyue; Chen Ning; Zhu Wanying; Hong Junli; Huang Changgao; Zhou Xuemin*, Vanillin-molecularly targeted extraction of stir bar based on magnetic field induced self-assembly of multifunctional Fe3O4@Polyaniline nanoparticles for detection of vanilla-flavor enhancers in infant milk powders, J Colloid Interf. Sci, 442:22-29, 2015.
[23] Wen Tingting; Zhu Wanying; Xue Cheng; Wu Jinhua; Han Qing; Wang Xi; Zhou Xuemin*; Jiang Huijun*, Novel electrochemical sensing platform based on magnetic field-induced self-assembly of Fe3O4@Polyaniline nanoparticles for clinical detection of creatinine, BiosensBioelectron, 56:180-185, 2014.
[24] Xue Cheng; Wang Xi; Zhu Wanying; Han Qing; Zhu Chunhong; Hong Junli; Zhou Xuemin*; Jiang Huijun, Electrochemical serotonin sensing interface based on double-layered membrane of reduced graphene oxide/polyaniline nanocomposites and molecularly imprinted polymers embedded with gold nanoparticles, Sensor. Actuat. B, 196:57-63, 2014.
[25] Han Qing; Wang Xi; Yang Zaiyue; Zhu Wanying; Zhou Xuemin*; Jiang Huijun*, Fe3O4@rGO doped molecularly imprinted polymer membrane based on magnetic field directed self-assembly for the determination of amaranth, Talanta, 123:101-108, 2014.
[26] Xue Cheng; Han Qing; Wang Yang; Wu Jinhua; Wen Tingting; Wang Ruoyu; Hong Junli; Zhou Xuemin*; Jiang Huijun*, Amperometric detection of dopamine in human serumby electrochemical sensor based on gold nanoparticles doped molecularly imprinted polymers, BiosensBioelectron, 49:199-203, 2013.
[27] Li Yun; Wen Tingting; Xue Cheng; Han Qing; Wang Yang; Hong Junli; Zhou Xuemin*; Jiang Huijun*, RGO LBL modified biomimetic electrochemical sensor for detection of Sildenafil in herbal sexual health products, BiosensBioelectron, 42:287-292, 2013.
[28] Wang Ruoyu; Wang Yang; Xue Cheng; Wen Tingting; Wu Jinhua; Hong Junli; Zhou Xuemin*, Selective separation and enrichment of glibenclamide in health foods using surface molecularly imprinted polymers prepared via dendritic grafting of magnetic nanoparticles, J Sep. Sci, 36(6):1015-1021, 2013.
[29] Wang Yang; Wu Jinhua; Xue Cheng; Wang Ruoyu; Wen Tingting; Hong Junli; Hu Qin; Li Fei; Zhou Xuemin*, Dumbbell-shaped stir bar coated with dendrimer-based MIPs for selective extraction and analysis of vardenafil and its analogue sildenafil in health foods, Anal. Methods, 5(17):4494-4500, 2013.
[30] Wu Xiaoli; Liu Jie; Wu Jinhua; Wang Yang; Xue Cheng; Wang Ruoyu; Hong Junli; Zhou Xuemin*, Molecular imprinting-based micro-stir bar sorptive extraction for specific analysis of Glibenclamide in herbal dietary supplements, J Sep. Sci, 35(24):3593-3599, 2012.
[31] Wang Shu; Wang Ruoyu; Wu Xiaoli; Wang Yang; Xue Cheng; Wu Jinhua; Hong Junli; Liu Jie; Zhou Xuemin*. Magnetic molecularly imprinted nanoparticles based on dendritic-grafting modification for determination of estrogens in plasma samples, J Chromatogr. B, 905:105-112, 2012.
[32] Wu Xiaoli; Wu Jinhua; Wang Shu; Wang Ruoyu; Li Yun; Wen Tingting; ZhongDandan; Hong Junli; Hu Qin;Zhou Xuemin*, An analytical method for estrogens in milk powder by pseudo template imprinted polymer coated fiber coupled with HPLC, Anal. Methods, 4:3300-3306, 2012.
[33] Wen Tingting; Xue Cheng; Li Yun; Wang Yang; Wang Ruoyu; Hong Junli; Zhou Xuemin*; Jiang Huijun*, Reduced graphene oxide-platinum nanoparticles composites based imprinting sensor for sensitively electrochemical analysis of 17β-estradiol, J Electroanal. Chem, 682:121-127, 2012.
[34] Yuan Lihua; Ma Jing; Ding Meijuan; Wang Shu; Wu Xiaoli; Li Yun; Ma Kunfang; Zhou Xuemin*; Li Fei*, Preparation of estriol–molecularly imprinted silica nanoparticles for determining oestrogens in milk tablets, Food Chem, 131(3):1063-1068, 2012.
[35] Yuan Lihua; Zhang Jun; Zhou Ping; Chen Jiaxing; Wang Ruoyu; Wen Tingting; Li Yun; Zhou Xuemin*; Jiang Huijun*, Electrochemical sensor based on molecularly imprinted membranes at platinum nanoparticles-modified electrode for determination of 17β-estradiol, BiosensBioelectron., 29(11):29-33, 2011.
[36] Wang Shu; Li Yun; Wu Xiaoli; Ding Meijuan; Xu Jinhui; Wang Ruoyu; Huang Wenyu; Zhou Ping; Ma Kunfang; Zhou Xuemin*; Du Shuhu*, Self-assembly molecularly imprinted polymers of 17β-estradiol on the surface of magnetic nanoparticles for selective separation and detection of estrogenic hormones in feeds, J Chromatogr. B, 879(25):2595-2600, 2011.
[37] Li Yun; Ding Meijuan; Wang Shu; Wang Ruoyu; Wu Xiaoli; Wen Tingting; Yuan Lihua; Dai Peng; Lin Yuhui; Zhou Xuemin*. Preparation of Imprinted Polymers at Surface of Magnetic Nanoparticles for the Selective Extraction of Tadalafil from Medicines, ACS Appl. Mater. Interfaces, 3(9):3308-3315, 2011.
[38] Ding Meijuan; Wu Xiaoli; Yuan Lihua; Wang Shu; Li Yun; Wang Ruoyu; Wen Tingting; Du Shuhu; Zhou Xuemin*, Synthesis of core–shell magnetic molecularly imprinted polymers and detection of sildenafil and vardenafil in herbal dietary supplements, J Hazard. Mater, 191(1–3):177-183, 2011.
[39] Wang Shu; Li Yun; Wu Xiaoli; Ding Meijuan; Yuan Lihua; Wang Ruoyu; Wen Tingting; Zhang Jun; Chen Lina; Zhou Xuemin*; Li Fei*, Construction of uniformly sized pseudo template imprinted polymers coupled with HPLC-UV for the selective extraction and determination of trace estrogens in chicken tissue samples., J Hazard. Mater, 186(2-3):1513-1519, 2011.
[40] Ma Jing; Yuan Lihua; Ding Meijuan; Wang Shu; Ren Feng; Zhang Jun; Du Shuhu; Li Fei; Zhou Xuemin*, The study of core–shell molecularly imprinted polymers of 17β-estradiol on the surface of silica nanoparticles, BiosensBioelectron, 26(5):2791-2795, 2011.
[41] Ma Jing; Yuan Lihua; Ding Meijuan; Zhang Jun; Zhang Qing; Xu Qunwei; Zhou Xuemin*, Determination of itopride hydrochloride in human plasma by RP-HPLC with fluorescence detection and its use in bioequivalence study,Pharmacol. Res, 59(3):189-193, 2009.