邵玲小，教授、博士生导师，国家高层次青年人才计划入选者、江苏省特聘教授。2019 年获浙江大学药理学博士学位，先后于耶鲁大学、康奈尔大学从事神经药理学与系统神经生物学研究。现任中国神经科学学会脑血管功能与疾病分会委员、中国药理学会心血管药理分会委员、江苏省毒理学会理事。获 Peter and Patricia Gruber International Research Award、中华医学科技奖三等奖、江苏省医学科技一等奖等荣誉。研究方向聚焦重大神经精神障碍的发病机制解析与药物靶点发现，围绕精神活性物质的神经可塑性调控、重大疾病风险基因的致病机制与分子靶标发现等方向开展系统研究，相关成果发表于Nature、Cell、Neuron、Molecular Psychiatry、Nature Communications、Journal of Experimental Medicine等国际知名期刊。
联系方式：lingxiao.shao@njmu.edu.cn
招生：药理学、药学专业硕士和药理学博士研究生；欢迎博士后加入；
代表性论文
1. Shao LX#, Liao C#, Davoudian PA, Savalia NK, Jiang Q, Wojtasiewicz C, Tan D, Nothnagel JD, Liu RJ, Woodburn SC, Bilash OM, Kim H, Che A, Kwan AC. Pyramidal cell types and 5-HT2A receptors are essential for psilocybin's lasting drug action. Nature, 642, 411–420 (2025).
2. Shao LX, Liao C, Gregg I, Davoudian PA, Savalia NK, Delagarza K, Kwan AC. Psilocybin induces rapid and persistent growth of dendritic spines in frontal cortex in vivo. Neuron, 109, 2535-2544.e4 (2021).
3. Jiang Q, Shao LX, Yao S, Savaila NK, Gilbert AD, Davoudian PA, Nothnagel JD, Tian G, Hung TS, Lai HM, Beier KT, Zeng H, Kwan AC. Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks. Cell, 189, 659–675 (2026).
4. Shao LX#, Jiang Q#, Liu XX#, Gong DM, Yin YX, Wu G, Sun NH, Wang CK, et al. Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons. Molecular Psychiatry, 24, 1461-1477 (2019).
5. Liu XX#, Yang L#, Shao LX#, He Y, Wu G, Bao YH, Lu NN, Gong DM, Lu YP, Cui TT, Sun NH, Chen DY, Shi WX, Fukunaga K, Chen HS, Chen Z, Han F, Lu YM. Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1-mediated reactive astrogliosis. Journal of Experimental Medicine, 217(1): e20180992 (2020).
6. Aboharb F#, Davoudian PA#, Shao LX, Liao C, Rzepka GN, Wojtasiewicz C, Indajang J, Dibbs M, Rondeau J, Sherwood AM, Kaye AP, Kwan AC. Classification of psychedelics and psychoactive drugs based on brain-wide imaging of cellular c-Fos expression. Nature Communications, 16, 1590 (2025).
7. Ali F, Shao LX, Gerhard DM, Sweasy K, Pothula S, Pittenger C, Duman RS, Kwan AC. Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense Shank3 mutation. Molecular Psychiatry, 26, 1945-1966 (2021).
8. Savalia NK, Shao LX, Kwan AC. A dendrite-focused framework for understanding the actions of ketamine and psychedelics. Trends in Neurosciences, 44, 260-275 (2021).
9. Davoudian PA, Shao LX, Kwan AC. Shared and distinct brain regions targeted for immediate early gene expression by ketamine and psilocybin. ACS Chemical Neuroscience, 14, 468-480 (2023).
10.Lu NN#, Tan C#, Sun NH, Shao LX, Liu XX, Gao YP, et al. Cholinergic Grb2-associated-binding protein 1 regulates cognitive function. Cerebral Cortex, 28(7), 2391-2404 (2018).
