岑瑶，博士，南京医科大学药学院副教授，硕士研究生导师。江苏省高校“青蓝工程”优秀青年骨干教师，南京医科大学优秀青年骨干教师。博士毕业于湖南大学化学生物传感与计量学国家重点实验室分析化学专业。主要利用CRISPR-Cas技术进行神经疾病与肿瘤早期诊断标志物检测新方法建立与治疗应用的研究。主持国家自然科学基金、江苏省自然科学基金等多项科研项目。以第一或通讯作者在国际知名期刊Nucleic Acids Research、Chemical Science、Analytical Chemistry、Small、Biosensors and Bioelectronics、Sensors and Actuators B: Chemical等发表论文多篇；以第一发明人授权专利3项。
研究方向：基于CRISPR-Cas技术的神经疾病与肿瘤早期诊断标志物检测新方法的建立与治疗应用
招生方向：药物分析；药学
联系方式：E-mail: yaocen@njmu.edu.cn
主持科研项目：
（1）国家自然科学基金青年基金项目（21705080）；
（2）江苏省基础研究计划自然科学基金—面上项目（BK20221304）；
（3）江苏省基础研究计划（自然科学基金）青年基金项目（BK20171043）；
代表性论文
(1) Tongshan Zuo, Chen Shen, Zhen Xie, Guanhong Xu, Fangdi Wei, Jing Yang, Xiaolei Zhu, Qin Hu*, Zheng Zhao*, Ben Zhong Tang*, Yao Cen*. FRAME: flap endonuclease 1 engineered PAM module for precise and sensitive CRISPR/Cas12a trans-cleavage activity modulating. Nucleic Acids Research, 2024, 52, 11884-11894.
(2) Qiutong Chen, Xinyi Xia, Zhigang Liang, Tongshan Zuo, Guanhong Xu, Fangdi Wei, Jing Yang, Qin Hu*, Zheng Zhao*, Ben Zhong Tang*, Yao Cen*. Self-assembled DNA nanospheres driven by carbon dots for microRNAs imaging in tumor via logic circuit. Small, 2024, 2310728.
(3) Lulu Qin, Wen-Jin Wang, Xinyi Xia, Tongshan Zuo, Yilin Cai, Guanhong Xu, Fangdi Wei, Suling Wang, Qin Hu, Zheng Zhao, Fan Zhang,* Ben Zhong Tang,* Yao Cen*. THRUST: translesion synthesis-driven hierarchical regulation using a template-activator construct for Cas12a activity. Chemical Science, 2025, 16, 12917-12926.
(4) Zhigang Liang, Yan Yu, Xiang Chen, Lulu Qin, Guanhong Xu, Fangdi Wei, Jing Yang, Qin Hu*, Yao Cen*. Breakthrough in LbCas12a chemical inhibitor screening: The firefly probe and its application in dual-mode biosensors. Analytical Chemistry, 2025, https://doi.org/10.1021/acs.analchem.5c03437.
(5) Tongshan Zuo, Xiang Chen, Yan Yu, Lulu Qin, Guanhong Xu, Fangdi Wei, Jing Yang, Chenglin Zhou, Lin Fan, Qin Hu*, Zheng Zhao*, Ben Zhong Tang*, Yao Cen*. BE-CATCH: bioamplifer-equipped CRISPR-Cas12a transduction system coupled with commercial pregnancy test strips to harness signal-on point-of-care detection. Analytical Chemistry, 2025, 97, 8947-8956.
(6) Xinyi Xia, Zhigang Liang, Guanhong Xu, Fangdi Wei, Jing Yang, Xiaolei Zhu, Chenglin Zhou, Jun Ye, Qin Hu*, Zheng Zhao*, Ben Zhong Tang*, Yao Cen*. Split crRNA precisely assisted Cas12a expansion strategy for simultaneous, discriminative, and low-threshold determination of two miRNAs associated with multiple sclerosis. Analytical Chemistry, 2025, 97, 2873-2882.
(7) Xinyi Xia, Qiutong Chen, Tongshan Zuo, Zhigang Liang, Guanhong Xu, Fangdi Wei, Jing Yang, Qin Hu*, Zheng Zhao*, Ben Zhong Tang*, Yao Cen*. DNA robots for CRISPR/Cas12a activity management and universal platform for biosensing. Analytical Chemistry, 2024, 96, 2620-2627.
(8) Xia Cheng, Dandan Ren, Guanhong Xu, Fangdi Wei, Jing Yang, Jian Xu, Lin Wang, Qin Hu*, Yao Cen*. Metal-organic frameworks-assisted nonenzymatic cascade amplification multiplexed strategy for sensing acute myocardial infarction related microRNAs. Biosensors and Bioelectronics, 2022, 196, 113706.
