岑瑶，博士，南京医科大学药学院副教授，硕士研究生导师。江苏省高校“青蓝工程”优秀青年骨干教师，南京医科大学优秀青年骨干教师。博士毕业于湖南大学化学生物传感与计量学国家重点实验室分析化学专业。主要利用CRISPR-Cas技术进行神经疾病与肿瘤早期诊断标志物检测新方法建立与治疗应用的研究。主持国家自然科学基金、江苏省自然科学基金等多项科研项目。以第一或通讯作者在国际知名期刊Nucleic Acids Research、Analytical Chemistry、Small、Biosensors and Bioelectronics、Sensors and Actuators B: Chemical等发表论文多篇；以第一发明人授权专利2项。
研究方向：神经疾病与肿瘤早期诊断标志物检测新方法的建立与治疗应用
招生方向：药物分析；药学
联系方式：E-mail: yaocen@njmu.edu.cn
教育背景及工作经历：
（1）2021/11-至今，南京医科大学，药学院药物分析学系，副教授；
（2）2019/09-2020/03，香港科技大学，化学系，访问学者；
（3）2016/09-2021/10，南京医科大学，药学院药物分析学系，讲师；
（4）2011/09-2016/06，湖南大学，化学生物传感与计量学国家重点实验室，分析化学专业，硕博连读，博士。
主持科研项目：
（1）国家自然科学基金青年基金项目（21705080）；
（2）江苏省基础研究计划自然科学基金—面上项目（BK20221304）；
（3）江苏省基础研究计划（自然科学基金）青年基金项目（BK20171043）；
代表性论文
(1) Tongshan Zuo, Chen Shen, Zhen Xie, Guanhong Xu, Fangdi Wei, Jing Yang, Xiaolei Zhu, Qin Hu*, Zheng Zhao*, Ben Zhong Tang*, Yao Cen*. FRAME: flap endonuclease 1 engineered PAM module for precise and sensitive CRISPR/Cas12a trans-cleavage activity modulating. Nucleic Acids Research, 2024, 52, 11884-11894.
(2) Xinyi Xia, Qiutong Chen, Tongshan Zuo, Zhigang Liang, Guanhong Xu, Fangdi Wei, Jing Yang, Qin Hu*, Zheng Zhao*, Ben Zhong Tang*, Yao Cen*. DNA robots for CRISPR/Cas12a activity management and universal platform for biosensing. Analytical Chemistry, 2024, 96, 2620-2627.
(3) Qiutong Chen, Xinyi Xia, Zhigang Liang, Tongshan Zuo, Guanhong Xu, Fangdi Wei, Jing Yang, Qin Hu*, Zheng Zhao*, Ben Zhong Tang*, Yao Cen*. Self-assembled DNA nanospheres driven by carbon dots for microRNAs imaging in tumor via logic circuit. Small, 2024, 2310728.
(4) Dandan Ren#, Qiutong Chen#, Xinyi Xia, Guanhong Xu, Fangdi Wei, Jing Yang, Qin Hu*, Yao Cen*. CRISPR/Cas12a-based fluorescence aptasensor integrated with two-dimensional cobalt oxyhydroxide nanosheets for IFN-γ detection. Analytica Chimica Acta, 2023, 1278, 341750.
(5) Xinyi Xia, Qiutong Chen, Dandan Ren, Guanhong Xu, Fangdi Wei, Jing Yang, Qin Hu*, Yao Cen*. Self-primer exponential Cas12a tandem reaction-amplified and [Cu(tz)] nanosheets based neoteric biosensing platform for quantifying multiple mTBI-related miRNAs. Sensors and Actuators B: Chemical, 2023, 393, 134327.
(6) Xia Cheng#, Xinyi Xia#, Dandan Ren, Qiutong Chen, Guanhong Xu, Fangdi Wei, Jing Yang, Lin Wang, Qin Hu*, Jianjun Zou*, Yao Cen*. Programmable CRISPR-Cas12a and self-recruiting crRNA assisted dual biosensing platform for simultaneous detection of lung cancer biomarkers hOGG1 and FEN1. Analytica Chimica Acta, 2023, 1240, 340748.
(7) Xia Cheng, Dandan Ren, Guanhong Xu, Fangdi Wei, Jing Yang, Jian Xu, Lin Wang, Qin Hu,* Yao Cen*. Metal-organic frameworks-assisted nonenzymatic cascade amplification multiplexed strategy for sensing acute myocardial infarction related microRNAs. Biosensors and Bioelectronics, 2022, 196, 113706.
(8) Sihan Rong, Qiutong Chen, Guanhong Xu, Fangdi Wei, Jing Yang, Dandan Ren, Xia Cheng, Xinyi Xia, Jiawei Li, Mingcong Gao, Qin Hu*, Yao Cen*. Novel and facile synthesis of heparin sulfur quantum dots via oxygen acceleration for ratiometric sensing of uric acid in human serum. Sensors and Actuators B: Chemical, 2022, 353, 131146.
(9) Jie Mei, Jian Bao, Xia Cheng, Dandan Ren, Guanhong Xu, Fangdi Wei, Yong Sun, Qin Hu*, Yao Cen*. Novel dual-emissive fluorescent silicon nanoparticles for detection of enzyme activity in supplements associated with lactose intolerance. Sensors and Actuators B: Chemical, 2021, 329, 129164.
(10) Xia Cheng, Yuying Chai, Jian Xu, Lin Wang, Fangdi Wei, Guanhong Xu, Yong Sun, Qin Hu*, Yao Cen*. Enzyme cascade reaction-based ratiometric fluorescence probe for visual monitoring the activity of alkaline phosphatase. Sensors and Actuators B: Chemical, 2020, 309, 127765.
(11) Xiaoman Xu‡, Dandan Ren‡, Yuying Chai, Xia Cheng, Jie Mei, Jian Bao, Fangdi Wei, Guanhong Xu, Qin Hu*, Yao Cen*. Dual-emission carbon dots-based fluorescent probe for ratiometric sensing of Fe(III) and pyrophosphate in biological samples. Sensors and Actuators B: Chemical, 2019, 298, 126829.
