张璐璐，南京医科大学药学院，副教授。

研究方向：药物代谢酶和转运体在神经精神网络中的作用以及对临床用药的影响。曾主持国家自然科学基金青年项目一项，发表SCI论文10余篇，累积影响因子近50分。教学方面主要承担《药理学》、《药物毒理学》、《药物代谢动力学》等课程的理论与实践教学。参编人民卫生出版社《药物毒理学》教材一部。

教育经历：

(1)2008.9-2011.6，中国药科大学，药物代谢动力学，博士

(2)2005.9-2008.6，中国药科大学，微生物与生化药学，硕士

(3)2001.9-2005.6，中国药科大学，生物工程，学士

工作经历：

(1)2019.10-2020.4，澳门大学，博士后，导师：燕茹

(2)2011.8至今，南京医科大学，讲师，副教授

主持或参加科研项目:

(1)国家自然科学基金青年科学基金项目，81202581，2013/01-2015/12，23万元，已结题，主持。

(2)江苏省自然科学基金青年科学基金项目，BK20170744，2017/07-2020/06，20万元，已结题，合作单位主持人。

(3)国家自然科学基金青年科学基金项目，81503160，2016/01-2018/12，17.9万元，已结题，参与。

(4)国家自然科学基金面上项目，81373041，2014/01-2017/12，72万，已结题，参与。

(5)国家自然科学基金青年科学基金项目，81202230，2013/01-2015/12，23万元，已结题，参与。

代表性研究成果

(1)Chengxiang Zhang^#, Heng Qin^#, Rui Zheng, Yubang Wang, Ting Yan, Fei Huan,Yang Han, Weicheng Zhu, Lulu Zhang*. A new approach for Alzheimer's disease treatment through P-gp regulation via ibuprofen. Pathology-Research and Practice. 2018,214(11):1765-1771.

(2)Yubang Wang, Heng Qin, Chengxiang Zhang, Fei Huan, Ting Yan, Lulu Zhang*.The Alterations in the Expression and Function of P-Glycoprotein inVitaminA-Deficient Rats as well as the Effect of Drug Disposition in Vivo. Molecules. 2015, 21(1):E46.

(3) Mian Wei^#, Rong Ma^#, Yan Liao, Youxiang Ding, Zhaohe Li, QinglongGuo, Renxiang Tan, Lulu Zhang*, Li Zhao*. Oroxylin A increases the sensitivity of temozolomide on glioma cells by hypoxia-inducible factor 1α/hedgehog pathway under hypoxia. J Cell Physiol. 2019,234(10):17392-17404.

(4)Yanxian Hu^#, Minghao Chen^#, Zhaoyu Wang, Yao Lan, Lan Tang, Menghua Liu, Jie Zhao, Ming Hu, Lulu Zhang*, Ling Ye*. Development of a validated UPLC–MS/MS method for determination of humantenmine in rat plasma and its application in pharmacokinetics and bioavailability studies. Biomedical Chromatography. 2017,31(12):e4017.

(5)Yanshen Ren^#, Lulu Zhang^#, Ziyan Zhou^#, Yanjun Luo, Suilou Wang, Shengtao Yuan, Yueqing Gu, Yungen Xu, Xiaoming Zha*. A new lysosome-targetable fluorescent probe with a large Stokes shift for detection of endogenous hydrogen polysulfides in living cells. Analytica Chimica Acta. 2019, 1056, 117-124.

(6)Yanshen Ren^#, Lulu Zhang^#, Ziyan Zhou^#, Suilou Wang*, Yungen Xu,Yueqing Gua and Xiaoming Zha*. A new fluorescent probe for quick and highly selective detection of hydrogen sulfide and its application in living cells. New J. Chem.2018, 42, 13884.

(7)Xi J^#, Xu S^#, Zhang L^#, Bi X, Ren Y, Liu YC, Gu Y, Xu Y, Lan F*, Zha X*. Design, synthesis and biological activity of 4-(4-benzyloxy)phenoxypiperidines as selective and reversible LSD1 inhibitors. Bioorg Chem. 2018 Aug;78:7-16.

(8)Hongxi Wu^#, Lulu Zhang^#, Xiaofang Gao, Xiuna Zhang, Jingjing Duan, Linjun You, Yan Cheng, Jinsong Bian, Qingyi Zhu^*, Yong Yang^*. Combination of sorafemib and enzalutamide as a potential new approach for the treatment of castration-resistant prostrate cancer. Cancer Letters.2017 Jan 28;385.

(9) Shen L^#, Zhang LL^#, Li H, Liu X, Yu XX, Hu P, Hui H^*, Guo QL^*, ZhangS^*. OroxylinA inhibits the generation of Tregs in non-small cell lungcancer.Oncotarget.2017 Jul 25;8(30).

联系方式：lulu_0219@njmu.edu.cn