张青,南京医科大学药学院,药剂学系,博士,副教授。于中国药科大学获得药剂学专业硕士学位,南京医科大学获得药理学专业博士学位,作为访问学者在美国斯坦福大学从事基于近红外二区荧光成像的诊疗一体化纳米材料研究。2004年至今在南京医科大学药学院任教。
研究方向为1. 以近红外二区荧光成像为核心的多模态诊疗技术;2. 基于介孔二氧化硅的靶向智能纳米递药系统;3. 运用分子印记机理的药物响应释放水凝胶。主持/参与国家自然科学基金、江苏省高校自然科学研究面上项目,安徽省重点实验室开放课题、南京医科大学科技发展基金重点项目,南京医科大学科技发展基金面上项目,南京医科大学教育研究课题青年基金,南京医科大学课程思政教学改革专项课题,等多项科研教学项目。共发表SCI和核心期刊论文三十余篇,获得授权发明专利1项。受邀为Nanomedicine: NBM,Colloids and Surfaces B: Biointerfaces,Scientific Reports,Journal of Microencapsulation等国际期刊审稿专家。主要承担药剂学、生物药剂学与药物动力学、临床药物代谢动力学等课程的教学工作,担任江苏省大学生创新创业训练计划指导教师,南京医科大学“5+3”本科生导师。指导江苏大学生创新创业训练计划项目(一般项目、省级重点项目各一项)。主持的教改课题获得南京医科大学教学成果二等奖1次,参与的教改课题获得教学成果奖1次。获得江苏省高校优秀中青年教师和校长境外研修计划资助。
近期发表的论文:
l、Han, X.; Fang, W.; Zhang, T.; Zhong, X.; Qian, K.; Jiang, Z.; Hu, R.; Shao, G.*; Zhang, L.*; Zhang, Q*. A facile phototheranostic nanoplatform integrating NIR-II fluorescence/PA bimodal imaging and image-guided surgery/PTT combinational therapy for improved antitumor efficacy. J. Mater. Sci. Technol. 2022, 130, 208-218.
2、Zhang, L.; Zhuang, W.; Yuan, Y.; Shen, J.; Shi, W.; Liu, G.; Wu, W.; Zhang, Q.; Shao, G.; Mei, Q.; Fan, Q. Novel Glutathione Activated Smart Probe for Photoacoustic Imaging, Photothermal Therapy, and Safe Postsurgery Treatment. ACS Appl. Mater. Interfaces 2022, 14, 24174-24186.
3、Zhu, B.; Chen, Y.; Lu, W.; Zhang, Q.; Gao, S.; Sun, L.; Chen, S.; Hu, R. A biodegradable long-term contraceptive implant with steady levonorgestrel release based on PLGA microspheres embedded in PCL-coated implant. J. Drug Deliv. Sci. Technol. 2022, 67, 102955.
4、Sun, L.; Nie, X.; Lu, W.; Zhang, Q.; Fang, W.; Gao, S.; Chen, S.; Hu, R. Mucus-Penetrating Alginate-Chitosan Nanoparticles Loaded with Berberine Hydrochloride for Oral Delivery to the Inflammation Site of Ulcerative Colitis. AAPS PharmSciTech 2022, 23, 179.
5、Chen, R.; Huang, Y.; Wang, L.; Zhou, J.; Tan, Y.; Peng, C.; Yang, P.; Peng, W.; Li, J.; Gu, Q.; Sheng, Y.; Wang, Y.; Shao, G.; Zhang, Q.*; Sun, Y.* Cetuximab functionalization strategy for combining active targeting and antimigration capacities of a hybrid composite nanoplatform applied to deliver 5-fluorouracil: Toward colorectal cancer treatment. Biomater. Sci. 2021, 9, 2279-2294.
6、Zhou, H.; Zhang, Q.; Cheng, Y.; Xiang, L.; Shen, G.; Wu, X.; Cai, H.; Li, D.; Zhu, H.; Zhang, R.; Li, L.; Cheng, Z. (64)Cu-labeled melanin nanoparticles for PET/CT and radionuclide therapy of tumor. Nanomed. 2020, 29, 102248.
7、Zhang, Q.; Zhou, H.; Chen, H.; Zhang, X.; He, S.; Ma, L.; Qu, C.; Fang, W.; Han, Y.; Wang, D.; Huang, Y.; Sun, Y.; Fan, Q.; Chen, Y.*; Cheng, Z.*, Hierarchically Nanostructured Hybrid Platform for Tumor Delineation and Image-Guided Surgery via NIR-II Fluorescence and PET Bimodal Imaging. Small 2019, 15 (45), e1903382.
8、Li, D.; He, S.; Wu, Y.; Liu, J.; Liu, Q.; Chang, B.; Zhang, Q.; Xiang, Z.; Yuan, Y.; Jian, C.; Yu, A.; Cheng, Z. Excretable lanthanide nanoparticle for biomedical imaging and surgical navigation in the second near‐Infrared window. Adv. Sci. 2019, 6, 1902042.
9、Zhang, X.; He, S.; Ding, B.; Qu, C.; Zhang, Q.; Chen, H.; Sun, Y.; Fang, H.; Long, Y.; Zhang, R.; Lan, X.; Cheng, Z. Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window. Chem. Eng. J. 2020, 385, 123959.
10、Zhang, Q.*; Chen, X.; Shi, H.; Dong, G.; Zhou, M.; Wang, T.; Xin, H.*, Thermo-responsive mesoporous silica/lipid bilayer hybrid nanoparticles for doxorubicin on-demand delivery and reduced premature release. Colloids Surf., B 2017, 160, 527-534.
11、Zhang, Q.*; Zhao, H.; Li, D.; Liu, L.; Du, S.*, A surface-grafted ligand functionalization strategy for coordinate binding of doxorubicin at surface of PEGylated mesoporous silica nanoparticles: Toward pH-responsive drug delivery. Colloids Surf., B 2017, 149, 138-145.
l2、Wang, X.#; Zhang, Q.#; Lv, L.; Fu, J.; Jiang, Y.; Xin, H.*; Yao, Q.*, Glioma and microenvironment dual targeted nanocarrier for improved antiglioblastoma efficacy. Drug Delivery 2017, 24 (1), 1401-1409.
l3、Zhang, Q.; Zhang, L.; Wang, P.; Du, S.*, Coordinate bonding strategy for molecularly imprinted hydrogels: toward pH-responsive doxorubicin delivery. J. Pharm. Sci. 2014, 103 (2), 643-651.
l4、Wang, P.; Zhang, A.; Jin, Y.; Zhang, Q.; Zhang, L.; Peng, Y.; Du, S.*, Molecularly imprinted layer-coated hollow polysaccharide microcapsules toward gate-controlled release of water-soluble drugs. RSC Advances 2014, 4 (50), 26063-26073.
专利:
l、朱东亚; 张青; 徐群为; 李瑞; 吴海银 ; 姜黄素脂质载体及其制备方法, 2011-5-4, 中国, CN200810155819.X
著作:
药学课程思政教学案例集,主编:韩峰,徐华娥,编委:张青,等,—北京:人民卫生出版社,2021.11. ISBN 978-7-117-31568-5