高原青

发布时间:2020-07-01浏览次数:10


高原青,博士,教授,博士生导师。2015年美国辛辛那提大学神经科学专业博士毕业。2012-2015年在德国慕尼黑亥姆霍兹研究所糖尿病与肥胖分所从事代谢疾病的中枢调控机制研究。2015-2017年在荷兰阿姆斯特丹医学中心从事下丘脑小胶质细胞与系统代谢控制的关系研究。2017年底回国,作为高层次引进人才受聘于南京医科大学药学院江苏省心脑血管药物重点实验室及药理系,主要研究代谢疾病的神经免疫调节机制,尤其是中枢调控机制与小胶质细胞参与的调控过程,研究成果发表在Cell ReportsDiabetesMolecular MetabolismGlia等国际知名杂志上。E-mailyuanqinggao@njmu.edu.cn

招生方向:药理学—神经内分泌与代谢疾病方向

研究方向:

1. 代谢疾病中神经免疫调控

2. 代谢性心脑血管疾病的中枢调控机制

3. 小胶质细胞参与的神经发育和脑肠轴互作机制

代表性论文:
(1) Gao, Yuanqing; Ottaway, Nickki; Schriever, Sonja C.; Legutko, Beata;Garcia-Caceres, Cristina; de la Fuente, Esther; Mergen, Clarita; Bour, Susanne;Thaler, Joshua P.; Seeley, Randy J.; Filosa, Jessica; Stern, Javier E.; Perez-Tilve, Diego; Schwartz, Michael W.; Tschoep, Matthias H.; Yi, Chun-Xia.
Hormones and Diet, but Not Body Weight, Control Hypothalamic Microglial Activity, GLIA, 2014.1, 62(1): 17~25

(2) Gao, Yuanqing; Vidal-Itriago, Andrés; Milanova, Irina; Korpel, Nikita L.; Kalsbeek, Martin J.; Zachariah Tom, Robby; Kalsbeek, Andries; Hofmann, Susanna M.; Yi, Chun-Xia. Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes body weight increase. Molecular metabolism, 2018.1, 7: 155~160

(3) Gao, Yuanqing; Vidal-Itriago, Andres; Kalsbeek, Martin J.; Layritz, Clarita; Garcia-Caceres, Cristina; Tom, Robby Zachariah; Eichmann, Thomas O.; Vaz, Frederic M.; Houtkooper, Riekelt H.; van der Wel, Nicole; Verhoeven, Arthur J.; Yan, Jie; Kalsbeek, Andries; Eckel, Robert H.; Hofmann, Susanna M.; Yi, Chun-Xia. Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity, CELL REPORTS, 2017.9.26, 20(13): 3034~3042 Cover paper

(4) Gao, Yuanqing; Layritz, Clarita; Legutko, Beata; Eichmann, Thomas O.; Laperrousaz, Elise; Moulle, Valentine S.; Cruciani-Guglielmacci, Celine; Magnan, Christophe; Luquet, Serge; Woods, Stephen C.; Eckel, Robert H.; Yi, Chun-Xia; Garcia-Caceres, Cristina; Tschoep, Matthias H. Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity, DIABETES, 2016.10, 66(10): 2555~2563

(5) Gao, Yuanqing; Bielohuby, Maximilian; Fleming, Thomas; Grabner, Gernot F.; Foppen, Ewout; Bernhard, Wagner; Guzman-Ruiz, Mara; Layritz, Clarita; Legutko, Beata; Zinser, Erwin; Garcia-Caceres, Cristina; Buijs, Ruud M.; Woods, Stephen C.; Kalsbeek, Andries; Seeley, Randy J.; Nawroth, Peter P.; Bidlingmaier, Martin; Tschoep, Matthias H. ; Yi, Chun-Xia. Dietary sugars, not lipids, drive hypothalamic inflammation, MOLECULAR METABOLISM, 2017.8, 6(8): 897~908

(6) Garcia-Caceres, Cristina; Quarta, Carmelo; Varela, Luis; Gao,Yuanqing; Gruber, Tim; Legutko, Beata; Jastroch, Martin; Johansson, Pia; Ninkovic, Jovica; Yi, Chun-Xia; Thuc, Ophelia Le; Szigeti-Buck, Klara; Cai, Weikang; Meyer, Carola W.; Pfluger, Paul T.; Fernandez, Ana M.; Luquet, Serge; Woods, Stephen C.; Torres-Aleman, Ignacio; Kahn, C. Ronald; Goetz, Magdalena; Horvath, Tamas L.; Tschoep, Matthias H., Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability, CELL, 2016.8.11, 166(4): 867~880

(7) Kim, Jae Geun; Suyama, Shigetomo; Koch, Marco; Lin, Sungho; Argente-Arizon, Pilar; Argente, Jesus; Liu, Zhong-Wu; Zimmer, Marcelo R.; Jeong, Jin Kwon; Szigeti-Buck, Klara; Gao, Yuanqing; Garcia-Caceres, Cristina; Yi, Chun-Xia; Salmaso, Natalina; Vaccarino, Flora M.; Chowen, Julie; Diano, Sabrina; Dietrich, Marcelo O.; Tschoep, Matthias H.; Horvath, Tamas L. Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. NATURE NEUROSCIENCE, 2014.7, 17(7): 908~910

(8) Yi, Chun-Xia; Walter, Marc; ; Pitra, Soledad; Legutko, Gao, Yuanqing, Beata; Kaelin, Stefanie; Layritz, Clarita; Garcia-Caceres, Cristina; Bielohuby, Maximilian; Bidlingmaier, Martin; Woods, Stephen C.; Ghanem, Alexander; Conzelmann, Karl-Klaus; Stern, Javier E.; Jastroch, Martin; Tschoep, Matthias H. TNF alpha drives mitochondrial stress in POMC neurons in obesity. NATURE COMMUNICATIONS, 2017.5.10, 8

(9) Morselli, Eugenia ; Fuente-Martin, Esther; Finan, Brian; Kim, Min; Frank, Aaron; Garcia-Caceres, Cristina; Navas, Carlos Rodriguez; Gordillo, Ruth; Neinast, Michael; Kalainayakan, Sarada P.; Li, Dan L.; Gao, Yuanqing; Yi, Chun-Xia; Hahner, Lisa; Palmer, Biff F.; Tschoep, Matthias H.; Clegg, Deborah J. Hypothalamic PGC-1 alpha Protects Against High-Fat Diet Exposure by Regulating ER alpha , CELL REPORTS, 2014.10.23, 9(2): 633~645