高原青，博士，教授，博士生导师。2015年美国辛辛那提大学神经科学专业博士毕业。2012-2015年在德国慕尼黑亥姆霍兹研究所糖尿病与肥胖分所从事代谢疾病的中枢调控机制研究。2015-2017年在荷兰阿姆斯特丹医学中心从事下丘脑小胶质细胞与系统代谢控制的关系研究。2017年底回国，作为高层次引进人才受聘于南京医科大学药学院江苏省心脑血管药物重点实验室及药理系，获得“江苏省333人才工程”、“江苏省双创团队”，南京医科大学“研究生导师星火团队“等荣誉称号。
主要研究代谢疾病的神经免疫调节机制，尤其是中枢调控机制与小胶质细胞参与的调控过程，研究成果发表在Molecular Psychiatry、Brain,behav,immunity、Cell Reports、Diabetes、Molecular Metabolism、Glia等国际知名杂志上。E-mail：yuanqinggao@njmu.edu.cn
招生方向：药理学—神经免疫与代谢疾病方向
研究方向：
1. 下丘脑参与的神经代谢调控机制
2. 代谢疾病中下丘脑与外周器官的通信机制
3. 小胶质细胞参与的神经发育和脑肠轴互作机制
代表性论文：
1.Sun J, Wang X, Sun R, Xiao X, Wang Y, Peng Y, Gao Y. Microglia shape AgRP neuron postnatal development via regulating perineuronal net plasticity. Mol Psychiatry. 2023 Nov 24.
2.Li N, Xiao X, Zhang H, Bai Z, Li M, Sun J, Dong Y, Zhu W, Fei Z, Sun X, Xiao P, Gao Y, Zhou D. Sterile soil mitigates the intergenerational loss of gut microbial diversity and anxiety-like behavior induced by antibiotics in mice. Brain Behav Immun. 2024 Jan;115:179-190.
3.Gao Y, Vidal-Itriago A, Kalsbeek MJ, Layritz C, García-Cáceres C, Tom RZ, Eichmann TO, Vaz FM, Houtkooper RH, van der Wel N, Verhoeven AJ, Yan J, Kalsbeek A, Eckel RH, Hofmann SM, Yi CX. Lipoprotein Lipase Maintains Microglial Innate Immunity in Obesity. Cell Rep. 2017 Sep 26;20(1 3):3034-3042.
4.Jiao H, Wang Y, Fu K, Xiao X, Jia MQ, Sun J, Wang J, Zhu G, Lyu D, Lu Q, Peng Y, Lv J, Su L, Gao Y. An orexin-receptor-2-mediated heart-brain axis in cardiac pain. iScience. 2024 Feb 1;27(3):109067.
5.Bian H, Wang J, Shan X, Li X, Wang Y, Sun R, Wang C, Lv J, Xing C, Hui C, Zhang D, Zhang C, Zhang Y, Zhao Y, Tian C, Gao Y, Su L, A portable on-demand therapeutic nitric oxide generation apparatus: New strategy for diabetic foot ulcers, Chemical Engineering Journal, Volume 480, 2024,148088.
6.Gao Y, Layritz C, Legutko B, Eichmann TO, Laperrousaz E, Moullé VS, Cruciani-Guglielmacci C, Magnan C, Luquet S, Woods SC, Eckel RH, Yi CX, Garcia-Caceres C, Tschöp MH.Disruption of Lipid Uptake in Astroglia Exacerbates Diet-Induced Obesity.Diabetes. 2017 Oct;66(10):2555-2563.
7.Peng Y, Xiao X, Ji T, et al. Reveal the pharmacodynamic substances and mechanism of an edible medicinal plant Rhodiola Crenulate in DSS-induced colitis through plasma pharmacochemistry and metabolomics. Food Science and Human Wellness, 2023
8.Li X, Chen X, Zheng L, Chen M, Zhang Y, Zhu R, Chen J, Gu J, Yin Q, Jiang H, Wu X, Ji X, Tang X, Dong M, Li Q, Gao Y, Chen H. Non-canonical STING-PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response. Acta Pharm Sin B. 2023 Dec;13(12):4765-4784.
9.Götz A, Lehti M, Donelan E, Striese C, Cucuruz S, Sachs S, Yi CX, Woods SC, Wright SD, Müller TD, Tschöp MH, Gao Y, Hofmann SM. Circulating HDL levels control hypothalamic astrogliosis via apoA-I. J Lipid Res. 2018 Sep;59(9):1649-1659
10.Fu K, Hui C, Wang X, Ji T, Li X, Sun R, Xing C, Fan X, Gao Y, Su L. Torpor-like Hypothermia Induced by A1 Adenosine Receptor Agonist: A Novel Approach to Protect against Neuroinflammation. Int J Mol Sci. 2023 Jul 3;24(13):11036.
11.Jia MQ, Wang YJ, Fu K, Jiao H, Sun J, Gao Y. Orexin receptor type 2 agonism inhibits thermogenesis in brown adipose tissue by attenuating afferent innervation. J Biomed Res. 2022 May 28;36(3):195-207.
12.Wolff SEC, Wang XL, Jiao H, Sun J, Kalsbeek A, Yi CX, Gao Y. The Effect of Rev-erbα Agonist SR9011 on the Immune Response and Cell Metabolism of Microglia.Front Immunol. 2020 Sep 25;11:550145.
13.Gao Y, Vidal-Itriago A, Milanova I, Korpel NL, Kalsbeek MJ, Tom RZ, Kalsbeek A, Hofmann SM, Yi CX.Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes body weight increase.Mol Metab. 2018 Jan;7:155-160
14.Gao Y, Bielohuby M, Fleming T, Grabner GF, Foppen E, Bernhard W, Guzmán-Ruiz M, Layritz C, Legutko B, Zinser E, García-Cáceres C, Buijs RM, Woods SC, Kalsbeek A, Seeley RJ, Nawroth PP, Bidlingmaier M, Tschöp MH, Yi CX.Dietary sugars, not lipids, drive hypothalamic inflammation.Mol Metab. 2017 Jun 20;6(8):897-908.
15.Gao Y, Ottaway N, Schriever SC, Legutko B, García-Cáceres C, de la Fuente E, Mergen C, Bour S, Thaler JP, Seeley RJ, Filosa J, Stern JE, Perez-Tilve D, Schwartz MW, Tschöp MH, Yi CX. Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia.2014 Jan;62(1):17-25.
