胡琴

发布时间:2020-07-01浏览次数:641


 胡琴,博士,南京医科大学教授/博士生导师。在教学方面,讲授分析化学课程,主编《分析化学》(案例版)、《基础化学》等教材和专著7部,被评为南医大教学名师、获“扬子江奖教金”优秀奖等奖项。在科研方面,主要从事半导体量子点和碳点纳米荧光材料、人工智能纳米材料的合成及其应用于生命系统中微量物质的分析等研究。主持多项省级、国家级科研课题。在国内外主要期刊发表SCI研究论文80余篇。以第一作者身份获授权国家发明专利8件,获校级“十一五”、“十二五”期间科技先进工作者光荣称号。学术兼职:中华医学会医学化学分会副理事长;江苏省科委科技项目、成果评审专家组成员;江苏省食品药品监督管理局新药审评委员;江苏省化学化工学会分析化学分会理事。


目前研究方向:

1、半导体量子点、碳点纳米荧光材料的合成及其作为荧光探针在药物分析中的应用。

2、金属-有机骨架材料的合成及其在样品预处理及分析中的应用。

3、分子印迹纳米材料的研制及其在样品预处理中的应用。

近期发表的SCI论文

1、Yuying Chai, Xia Cheng, Guanhong Xu, Fangdi Wei, Jian Bao, Jie Mei,  Dandan Ren, Qin Hu, Yao Cen. A nanoplatform based on metal–organic frameworks and coupled exonuclease reaction for the fluorimetric determination of T4 polynucleotide kinase activity and inhibition, Microchimica Acta 2020, 187, 243

2、Xia Cheng, Yuying Chai, Jian Xu, Lin Wang, Fangdi Wei, Guanhong Xu, Yong Sun, Qin Hu, Yao Cen. Enzyme cascade reaction-based ratiometric fluorescence probe for visual monitoring the activity of alkaline phosphatase, Sensors and Actuators B: Chemical, 2020, 309,127765

3、Menglan Shi, Yao Cen, Guanhong Xu, Fangdi Wei, Xiaoman Xu, Xia Cheng, Yuying Chai, Muhammad Sohail, Qin Hu. Ratiometric fluorescence monitoring of α-glucosidase activity based on oxidase-like property of MnO2 nanosheet and its application for inhibitor screening. Anal. Chim. Acta. 2019, 1077: 225-231

4、Xiaoman Xu, Yao Cen, Guanhong Xu, Fangdi Wei, Menglan Shi, Qin Hu. A ratiometric fluorescence probe based on carbon dots for discriminative and highly sensitive detection of acetylcholinesterase and butyrylcholinesterase in human whole blood, Biosensors and Bioelectronics, 2019, 131, 232-236

5、Yujie Ma, Guanhong Xu, Fangdi Wei, Yao Cen, Menglan Shi, Xiaoman Xu, Muhammad Sohail, Qin Hu. One-pot synthesis of a magnetic, ratiometric fluorescent nanoprobe by encapsulating Fe3O4 magnetic nanoparticles and dual-emissive rhodamine B modified carbon dots in metal–organic framework for detection of HClO, ACS Applied Materials & Interfaces, 2018, 10, 20801-20805

6、Xiaoman Xu, Guanhong Xu, Fangdi Wei, Yao Cen, Menglan Shi, Xia Cheng, Yuying Chai, Muhammad Sohail, Qin Hu.Carbon dots coated with molecularly imprinted polymers: a facile bioprobe for fluorescent determination of caffeic acid, Journal of Colloid And Interface Science, 2018, 529, 568-574

7、Yunsu Ma, Yao Cen, Muhammad Sohail, Guanhong Xu, Fangdi Wei, Menglan Shi, Xiaoman Xu, Yueyue Song, Yujie Ma, Qin Hu. A Ratiometric Fluorescence Universal Platform Based on N, Cu Codoped Carbon Dots to Detect Metabolites Participating in H2O2-generation Reactions, ACS Applied Materials & Interfaces, 2017, 9: 33011-33019


代表性发明专利

1. 定量检测血清中可代谢产生H2O2的生物分子的方法

专利号:ZL 201710491569.6

发明人:胡琴,马云苏,许贯虹,魏芳弟,岑瑶

2.一种定量检测奶粉中β-乳球蛋白的方法   

专利号:ZL 201710598812.4

发明人:胡琴,时梦岚,许贯虹,魏芳弟,岑瑶,徐晓曼,程霞,柴煜莹

3.碲化镉量子点表面对氨基酚印迹聚合物及其制备方法和应用

专利号:ZL 2013 1 0456073.7   

发明人:胡琴,路霞林,魏芳弟,许贯虹,刘利萍,周萍,杨静