陈宏山，教授，博士生导师，南京医科大学药学院副院长，江苏省心脑血管药物重点实验室常务副主任。江苏省特聘教授，江苏省特聘医学专家，江苏省六大人才高峰，江苏省双创团队领军人才。中国病理生理学会生物活性小分子专业委员会秘书长。2008年至2016年，在美国康奈尔及爱因斯坦医学院学习工作。2017年初加入南京医科大学药学院江苏省心脑血管药物重点实验室。近年来在Cell Research、Molecular Cell、Nature Structural and Molecular Biology、Nature Protocols、Acta Pharmaceutica Sinica B、Cancer Research、Critical Care 等国际知名杂志上发表多项代表性成果。承担课题多项。研究方向：心血管及衰老表观遗传学机制及药物开发。Email: hongshanchen@njmu.edu.cn
近年代表性论文(中科院1区)：
1. TRAP1 drives smooth muscle cell senescence and promotes atherosclerosis via HDAC3-primed histone H4 lysine 12 lactylation.
European Heart Journal. 2024. 通讯作者(IF, 37.6)
2. Cathepsin B S-nitrosylation promotes ADAR1-mediated editing of its own mRNA transcript via an ADD1/MATR3 regulatory axis.
Cell Research. 2023. 共同通讯(IF, 44.1)
3. Combating Atherosclerosis Disease with Chirality/Phase Dual-Engineered Nanozyme Featuring Microenvironment Programmed Seno-Lytic/-Morphic Actions.
Advanced Materials. 2024. 共同通讯(IF, 29.4)
4. ASF1A-dependent P300-mediated histone H3 lysine 18 lactylation promotes atherosclerosis by regulating EndMT.
Acta Pharmaceutica Sinica B. 2024. 通讯作者(IF, 14.5)
5. Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation.
Cell Reports. 2024. 通讯作者(IF, 8.8)
6. ncRNA JPX-enriched chromatin microenvironment mediates vascular smooth muscle.
Arteriosclerosis, Thrombosis, and Vascular Biology. 2024. 通讯作者(IF, 8.7)
7. Non-canonical STING-PERK pathway dependent epigenetic regulation of vascular endothelial dysfunction via integrating IRF3 and NF-κB in inflammatory response.
Acta Pharmaceutica Sinica B. 2023. 通讯作者(IF, 14.5)
8. Phagocytosis of glioma cells enhances the immunosuppressive phenotype of bone marrow-derived macrophages.
Cancer Research. 2023. 共同通讯(IF, 11.2)
9. Single-cell RNA Sequencing unveils the communications between malignant T and myeloid cells contributing to tumor growth and immunosuppression in cutaneous T-cell lymphoma.
Cancer Letters. 2022. 共同通讯(IF, 9.7)
10. Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB-p300-BRD4 axis.
Acta Pharmaceutica Sinica B. 2022. 通讯作者(IF, 14.9)
11. Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-kB pathway.
Genes & Diseases. 2022. 通讯作者(IF, 7.2)
12. Implications of Cardiac Markers in Risk-Stratification and Management for COVID-19 Patients.
Critical Care. 2021. 通讯作者(IF, 19.3)
13. Sucrose preference test for measurement of stress-induced anhedonia in mice.
Nature Protocols. 2018. 共同通讯(IF, 12.4)
14. Melatonin regulates PARP-1 to control the senescence-associated secretory phenotype (SASP) in human fetal lung fibroblast cells.
Journal of Pineal Research. 2017. 通讯作者(IF, 15.2)
15. A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression.
Oncogene. 2017. 第一及共同通讯(IF, 7.9)
16. MacroH2A1 and ATM play opposing roles in paracrine senescence and the senescence-associated secretory phenotype.
Molecular Cell. 2015. 第一作者(IF, 15.5)
17. MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation.
Nature Structural and Molecular Biology. 2014. 第一作者(IF, 15.3)
