姓名：都述虎
性别：男
学历学位：研究生，博士
职称职务：教授
硕博导师：博士生导师，江苏省“六大人才高峰”入选者
社会兼职：国家自然科学基金评审专家，国家和江苏省药品审评专家，国家“食品安全关键技术研发”重点专项评审(会评)专家，江苏省科技成果转化项目（生物医药）评审专家，江苏省科技咨询专家，北京、浙江、山东、四川和重庆等省市自然科学基金评审专家，Biosens. Bioelectron., J. Chromatogr. A, Analyst, Anal. Chim. Acta, Food Chem.和Talanta等国际期刊审稿人。
主要研究方向：现代药物分析新技术与新方法。
主要研究成果：近年来，主要开展拉曼光谱、荧光纳米传感器和分子印记技术等研究，并成功地应用于生物/疾病标志物检测和天然产物/中药活性成分、农药及药物残留等复杂样品分离与分析；并在Anal. Chem., J. Nat. Prod., Biosens. Bioelectron., J. Chromatogr. A, Analyst和Anal. Chim. Acta等重要期刊发表论文40余篇，授权发明专利4项。先后主持过国家自然科学基金项目4项、国家863 计划项目1项、高等学校博士学科点专项科研基金1项、江苏省“六大人才高峰”项目1项、安徽省“十五”攻关课题1项、安徽省优秀青年基金2项；曾获安徽省科学技术研究成果奖3项、新药临床批件2项、2017年获江苏中医药科学技术奖二等奖1项(芯-壳型分子印记材料设计合成及其对中药药效物质快速富集与分析)、2020年获华夏医学科技奖三等奖1项(基于表面分子印记技术的中药药效物质快速富集与分析新策略)，2020年获首届全国药学专业学位研究生教育教学成果二等奖1项(“分合、协同”药学专业学位研究生创新人才培养的途径与实践)；主编《药物分析》(华中科技大学出版社)1部，副主编“十四五”普通高等教育医学类研究生规划教材《现代药物分析》(科学出版社)，参编《药物分析学》(高等教育出版社)1部和《天然药物化学》(科学出版社和人民卫生出版社)2部。
学历与研究工作简历：
1983.9-1987.7 安徽中医药大学，药学专业，获理学学士学位
1997.9-2001.7 中国药科大学，药物分析专业，获理学硕士学位
2001.9-2004.6 中国药科大学，药物分析专业，获理学博士学位
1987.7-2004.10 安徽省医学科学研究所药化研究室助理研究员、副研究员、研究员
2004.11-2015.2 南京医科大学药学院药学系教授
2015.3-2016.3 国家食品药品监督管理总局药品审评中心挂职
2016.4-至今 南京医科大学药学院药物分析学系教授
2018.1-2021.12：Ehrlich反应诱导表面增强共振拉曼散射及其在吲哚类植物生长素选择性检测中的应用(21775073，国家自然科学基金委员会资助，主持人)
2013.1-2016.12 SERS活性的芯-壳型分子印记传感器对青霉素类药物中过敏原的快速检测(21275075，国家自然科学基金委员会资助，主持人)
2012.1-2014.12 新型分离介质多重分子印记材料设计合成及其在中药药效物质的富集提取中的应用(20113234110001, 2011年度高等学校博士学科点专项科研基金资助, 主持人)
2011.1-2013.12 荧光信号分子印记聚合物对食品中氮杂环类有害物残留的检测(21075066，国家自然科学基金委员会资助，主持人)
2008.1-2010.11 高选择性分离富集材料纳米硅胶表面分子印记聚合物的制备及其在重要的有机磷、磺酰脲类农药残留检测中应用(2008AA10Z421，国家863计划资助，主持人)
2008.1-2010.12 芯-壳结构复合纳米分子印记硅胶的制备及其在葛根异黄酮分离中的应用(07-C-009，江苏省“六大人才高峰”资助，主持人)
2007.1-2007.12 分子印记纳米硅胶设计合成及其对天然活性甾体皂苷的高选择性分离(30672532，国家自然科学基金委员会资助，主持人)
承担教学改革课题情况：
2019.10.1-2021.9.31：药学专业学位案例教学研究与推广(2019YX05，全国药学专业学位研究生教育指导委员会资助，主持人)
发表论文情况：
1. 拉曼光谱
[1] Liping Wang, Jinling Mo, Yuhong Xia, Tian Lu, Yang Jin, Yan Peng, Liying Zhang*, Yulin Tang*, Shuhu Du*. Monitoring allergic reaction to penicillin based on ultrasensitive detection of penicilloyl protein using alkyne response SERS immunosensor. Journal of Pharmaceutical and Biomedical Analysis, 2021, 206 : 114377
[2] Yuhong Xia, Tian Lu, Liping Wang, Jinling Mo, Yang Jin, Liying Zhang*, Shuhu Du*. Intrinsic Raman signal amplification for rapid identification and detection of methylglyoxal in manuka honey. Analytica Chimica Acta, 2021, 1181 : 338902
[3] Tian Lu, Liping Wang, Yuhong Xia, Yang Jin, Liying Zhang*, Shuhu Du*. A multimer-based SERS aptasensor for highly sensitive and homogeneous assay of carcinoembryonic antigens. Analyst, 2021, 146, 3016–3024
[4] 彭艳，张丽颖，金阳，杨钊，陆兔林，金传山，都述虎*.拉曼光谱法快速测定矿物药石膏中二水硫酸钙的含量. 药物分析，2021,41(7) :1266-1271
[5]彭 艳，张丽颖，金 阳，杨 钊，陆兔林，金传山，都述虎*.煅石膏中无水硫酸钙拉曼光谱定量分析方法研究. 中草药，2021,52(21): 6683-6686
[6] 彭艳，张丽颖，金阳，杨钊，陆兔林，金传山，都述虎*.山药及麸炒山药拉曼指纹图谱分析. 中成药，2021, 43(12): 3403-3408
[7] Chunchen Zheng#, Liying Zhang#, Fangyuan Wang , Yueqing Cai, Shuhu Du*, Zhongping Zhang. Silver nanoparticles/activated carbon composite as a facile SERS substrate for highly sensitive detection of endogenous formaldehyde in human urine by catalytic reaction. Talanta, 2018, 188 : 630–636
[8] Xiaoling Gu#, Yang Jin#, Fang Dong, Yueqing Cai, Zhengyi You, Junhui You, Liying Zhang, Shuhu Du*. Toward rapid analysis, forecast and discovery of bioactive compounds from herbs by jointly using thin layer chromatography and ratiometric surface-enhanced Raman spectroscopy technique. Journal of Pharmaceutical and Biomedical Analysis, 2018,153 : 9–15
[9] Fangyuan Wang, Xiaoling Gu, Chunchen Zheng, Fang Dong, Liying Zhang, Yueqing Cai, Zhengyi You, Junhui You, Shuhu Du*, and Zhongping Zhang. Ehrlich reaction evoked multiple spectral resonances and gold nanoparticle hotspots for Raman detection of plant hormone. Analytical Chemistry, 2017, 89 (17) : 8836–8843
[10] Meihui Qi, Xiaoyan Huang, Yujie Zhou, Liying Zhang, Yang Jin, Yan Peng, Huijun Jiang, Shuhu Du*. Label-free surface-enhanced Raman scattering strategy for rapid detection of penicilloic acid in milk products. Food Chemistry, 2016, 197(Part A): 723–729
[11] Liying Zhang†, Yang Jin†, Xiaoyan Huang, Yujie Zhou, Shuhu Du,* Zhongping Zhang. Ligand replacement approach to Raman-responded molecularly imprinted monolayer for rapid determination of penicilloic acid in penicillin. Analytical Chemistry, 2015, 87 (23) : 11763–11770
[12] Hui Mao, Meihui Qi, Yujie Zhou , Xiaoyan Huang , Liying Zhang , Yang Jin , Yan Peng, Shuhu Du*. Discrimination of sibutramine and its analogues based on surface-enhanced Raman spectroscopy and chemometrics: toward rapid detection of synthetic anorexic drug in natural slimming product. RSC Advances, 2015, 5(8): 5886–5894
[13] Liying Zhang, Yang Jin, Hui Mao, Lei Zheng, Jiawei Zhao, Yan Peng, Shuhu Du*, Zhongping Zhang*. Structure-selective hot-spot Raman enhancement for direct identification and detection of trace penicilloic acid allergen in penicillin. Biosensors and Bioelectronics, 2014, 58:165–171
2. 荧光纳米传感器
[14] Jiangrong Ji,‡ Xin Xu,‡ Panpan Chen, Jiafeng Wu,Yang Jin, Liying Zhang, Shuhu Du*. Base amount-dependent fluorescence enhancement for the assay of vascular endothelial growth factor 165 in human serum using hairpin DNA-silver nanoclusters and oxidaized carbon nanoparticles. Microchimica Acta, 2020, 187(11) : 629
[15] Panpan Chen,Xin Xu, Jiangrong Ji, Jiafeng Wu, Tian Lu, Yuhong Xia, Liping Wang , Junting Fan, Yang Jin, Liying Zhang, Shuhu Du*. Specific and visual assay of iodide ion in human urine via redox pretreatment using ratiometric fluorescent test paper printed with dimer DNA silver nanoclusters and carbon dots. Analytica Chimica Acta, 2020, 1138 : 99-107
[16] Junhui You, Jiangrong Ji. Jiafeng Wu. Siwan Wang, Panpan Chen, Rongchen Mao,Yang Jin, Liying Zhang, Shuhu Du*. Ratiometric fluorescent test pen filled with a mixing ink of carbon dots and CdTe quantum dots for portable assay of silver ion on paper. Microchimica Acta, 2020, 187 : 391
[17] Xin Xu , Jiangrong Ji , Panpan Chen , Jiafeng Wu , Yang Jin , Liying Zhang , Shuhu Du*. Salt-induced gold nanoparticles aggregation lights up fluorescence of DNA-silver nanoclusters to monitor dual cancer markers carcinoembryonic antigen and carbohydrate antigen 125. Analytica Chimica Acta, 2020, 1125 : 41-49
[18] Junhui You, Zhengyi You, Xin Xu, Jiangrong Ji, Tian Lu,Yuhong Xia, Lipin Wang, Liying Zhang, Shuhu Du*. A split aptamer-labeled ratiometric fluorescent biosensor for specific detection of adenosine in human urine. Microchimica Acta, 2019, 186 : 43
[19] Qiang Da,Yuanyuan Gu, Xiafeng Peng, Liying Zhang*, Shuhu Du*. Colorimetric and visual detection of mercury(II) based on the suppression of the interaction of dithiothreitol with agar-stabilized silver-coated gold nanoparticles. Microchimica Acta, 2018, 185: 357
[20] Yueqing Cai, Junhui You, Zhengyi You, Fang Dong, Shuhu Du*, Liying Zhang*. Profuse color-evolution-based fluorescent test paper sensor for rapid and visual monitoring of endogenous Cu2+ in human urine. Biosensors and Bioelectronics, 2018, 99 : 332–337
[21] Xiaoyan Huang†, Yujie Zhou†, Cui Liu, Ruilong Zhang, Liying Zhang, Shuhu Du*, Bianhua Liu, Ming-Yong Han, Zhongping Zhang*. A single dual-emissive nanofluorophore test paper for highly sensitive colorimetry-based quantification of blood glucose. Biosensors and Bioelectronics, 2016, 86 : 530–535
[22] Yujie Zhou†, Xiaoyan Huang†, Cui Liu, Ruilong Zhang, Xiaoling Gu, Guijian Guan, Changlong Jiang, Liying Zhang, Shuhu Du*, Bianhua Liu, Ming-Yong Han, Zhongping Zhang*. Color-multiplexing-based fluorescent test paper: dosage-sensitive visualization of arsenic(III) with discernable scale as low as 5 ppb. Analytical Chemistry, 2016, 88 (12) : 6105–6109
3.分子印记技术
[23] Peng Wang†, Aixia Zhang†, Yang Jin, Qing Zhang, Liying Zhang, Yan Peng, Shuhu Du*. Molecularly imprinted layer-coated hollow polysaccharide microcapsules toward gate controlled release of water-soluble drugs. RSC Advances, 2014, 4 (50): 26063-26073
[24] Lei Zheng, Hui Mao, Liying Zhang, Yang Jin, Yujie Zhou, Yan Peng, Shuhu Du*. Aminopyrine Raman spectral features characterised by experimental and theoretical methods: Toward rapid SERS detection of synthetic antipyretic-analgesic drug in traditional Chinese medicine. Analytial Methods, 2014, 6(15):5925–5933
[25] Qing Zhang, Liying Zhang, Peng Wang, Shuhu Du*. Coordinate bonding strategy for molecularly imprinted hydrogels: Toward pH-responsive doxorubicin delivery. Journal of Pharmaceutical Sciences, 2014, 103(2):643-651
[26] Jiawei Zhao†, Li Nie†, Liying Zhang, Yang Jin, Yan Peng, Shuhu Du*, Nan Jiang*. Molecularly imprinted layer-coated silica nanoparticle sensors with guest-induced fluorescence enhancement: theoretical prediction and experimental observation. Analytial Methods, 2013, 5(12):3009-3015
[27] Jing Luo , Liying Zhang , Danjun Chen , Peng Wang , Jiawei Zhao, Yan Peng , Shuhu Du*, Zhongping Zhang*. Molecularly imprinted layer-coated monodisperse spherical silica microparticles toward affinity-enrichment of isoflavonoid glycosides from Radix Puerariae. Analyst, 2012, 137 (12):2891-2902
[28] Ying Xie, Danjun Chen, Jiawei Zhao, Yan Peng, Nan Jiang, Xuemin Zhou, Shuhu Du*, Zhongping Zhang*. An efficient hybrid design to prepare highly dense imprinted layer-coated silica particles for selective uptake of trace metsulfuron-methyl from complicated matrices. RSC Advances, 2012, 2(1) : 273-283
[29] Shu Wang, Yun Li, Meijuan Ding, Xiaoli Wu, Jinhui Xu, Ruoyu Wang, Tingting Wen, Wenyu Huang, Ping Zhou, Kunfang Ma, Xuemin Zhou∗, Shuhu Du∗. Self-assembly molecularly imprinted polymers of 17β-estradiol on the surface of magnetic nanoparticles for selective separation and detection of estrogenic hormones in feeds. Journal of Chromatography B, 2011, 879 (25): 2595-2600
[30] Qing Lu, Xuemei Chen, Li Nie, Jing Luo, Huijun Jiang, Lina Chen, Qin Hu, Shuhu Du*, Zhongping Zhang. Tuning of the vinyl groups’ spacing at surface of modified silica in preparation of high density imprinted layer-coated silica nanoparticles: A dispersive solid-phase extraction materials for chlorpyrifos. Talanta, 2010, 81(3) : 959–966
[31] Yan Peng , Ying Xie , Jing Luo , Li Nie , Yun Chen, Lina Chen , Shuhu Du*, Zhongping Zhang*. Molecularly imprinted polymer layer-coated silica nanoparticles toward dispersive solid-phase extraction of trace sulfonylurea herbicides from soil and crop samples. Analytica Chimica Acta, 2010
, 674(2) : 190–200
[32] Chunxiao Zhai, Qing Lu, Xuemei Chen, Yan Peng, Lina Chen, Shuhu Du*. Molecularly imprinted layer-coated silica nanoparticles toward highly selective separation of active diosgenin from Dioscorea nipponica Makino. Journal of Chromatography A, 2009, 1216 (12) : 2254–2262
专利授权情况：
[1] 都述虎，蔡月青，尤军辉，张丽颖. 一种用于可视化检测铜离子的荧光宽色度试纸及其制备方法和应用. 2020.1，中国，201710556279.5
[2] 都述虎，彭艳，罗晶，陆庆，陈立娜，李飞，杨伟. 红景天苷及其杂质的分离方法和红景天苷及其杂质的RP-HPLC分析法，2011.1，中国，200810196164.0
[3] 都述虎，彭艳，陆庆，罗晶，谢颖，陈雪梅，陈丹君，聂力，陈立娜，李飞. 磺酰脲类除草剂纳米硅胶表面分子印记聚合物的制备方法，2011.12，中国，200910234239.4
[4] 都述虎，陆庆，彭艳，陈雪梅，谢颖，罗晶，聂力，陈丹君，陈立娜，胡琴. 有机磷类杀虫剂纳米硅胶表面分子印记聚合物的制备方法，2012.7，中国，200910234240.7
