陈芸

发布时间:2020-07-01浏览次数:13132



陈芸,博士,教授、博士生导师,南京医科大学国际教育学院院长。博士毕业于美国明尼苏达大学,期间在美国Arriaga实验室从事乳腺肿瘤细胞多药耐药机制的研究,之后又在美国Charles River实验室参与了多肽及蛋白质等大分子药物的药代动力学研究,并于2016年以访问学者的身份在美国宾夕法尼亚大学医学院进行科学研究和交流。2008年,被南京医科大学作为海外高层次人才引进,特聘为教授、博士生导师,兼任南京医科大学生殖医学和子代健康全国重点实验室研究员,江苏省人民医院伦理委员会委员,南京医科大学第二附属医院临床试验中心副主任,江苏省药学会委员、临床药学分会委员,以及南京市药物再评价专业委员会委员等。国家自然科学基金优秀青年科学基金获得者,中华医学会青年科技奖获得者,并曾入选江苏省333高层次人才培养工程,江苏省六大人才高峰,以及南京市高层次人才等。

 

主要科研方向:质谱检测/多组学研究/单细胞研究

 

代表性科研项目:国家自然科学基金优秀青年科学基金(21722504)、国家自然科学基金面上项目(22374081221740682167508921175071)、国家自然科学基金青年科学基金(20905037)、江苏省重点研发计划(BE2022796BE2018725)、江苏省自然科学基金面上项目(BK20221303)、东南大学-南京医科大学-中国药科大学合作研究重点项目(2242019K3DNZ2)、东南大学-南京医科大学合作项目重点项目(2242017K3DN12)等多个项目。

 

主要科研成果:以通讯作者或第一作者在Nature CommunicationsNature Cell BiologyAngewandte Chemie International EditionAdvanced Functional MaterialsSmallChemical ScienceACS Applied Materials&InterfacesClinical ChemistryChemical CommunicationAnalytical Chemistry等高水平期刊上发表论文60余篇,技术方法同时被国内外许多实验室借鉴和采用,总引次数>400。另外,主编中文专著1部,参编中文专著3部、英文专著3部、临床分子诊断学指南1部。另外,申请人目前已申请了包括核酸适配体-多肽复合物探针及其制备方法和应用在内的8项专利,已有6项授权(ZL201610202840.5ZL201710310924.5ZL201710997052.4ZL201810513170.8ZL201910699054.4),1项转化(ZL201410137337.7),并有部分成果在多家企业和三甲医院推广和应用。

 

招生方向:临床药学(学术学位)、药学(专业学位)硕博士

 

近五年代表论文:

1.Yang Y, Wang Y, Wang Z, Yan H, Gong Y, Hu Y, Jiang Y, Wen S, Xu F, Wang B, Humphries F*, Chen, Y*, Wang X*, Yang S*. ECSIT facilitates memory CD8+ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis. Nat Cell Biol. 2024. doi:10.1038/s41556-024-01351-9.

2.Liu C. Y, Chen Y*, Hu, J*. Identification of the Electrogenerated Hidden Nitrenium Ions by In Situ Mass Spectrometry. Anal Chem. 2024;96(8):3354-3361. doi:10.1021/acs.analchem.3c04315.

3.Shi X, Liu C, Zheng W, Cao X, Li W, Zhang, D, Zhu J, Zhang X, Chen, Y*. Proteomic Analysis Revealed the Potential Role of MAGE-D2 in the Therapeutic Targeting of Triple-Negative Breast Cancer. Mol Cell Proteomics. 2024;23(1):100703. doi:10.1016/j.mcpro.2023.100703.

4.Zhang W, Xu F, Yao J, Mao C, Zhu M, Qian M, Hu J, Zhong H, Zhou J, Shi X, Chen Y*. Single-cell metabolic fingerprints discover a cluster of circulating tumor cells with distinct metastatic potential. Nat Commun. 2023;14(1):2485. doi:10.1038/s41467-023-38009-3.

5.Zhu H, Chen Z, Chen Y*, Zhu J*. Affinities and Kinetics Detection of Protein-Small Molecule Interactions with a Monolayer MoS2 -Based Optical Imaging Platform. Small. 2022;18(29):e2202622. doi:10.1002/smll.202202622

6.Li X, Zhu J, Shi X, Wang Z, Chen X, Zhang, X, Chen Y*. Steric Hindrance On-Off Mass-Tagged Probe Set Enables Detection of Protein Homodimer in Living Cells. ACS Appl Mater Interfaces. 2022;14(49):54517-54526. doi:10.1021/acsami.2c15010.

7.. Zhu J, Bai Y, Chen X, Hu L, Zhang W, Liu C, Shao H*, Sun J*, Chen, Y*. Ultrasensitive detection of β-lactamase-associated drug-resistant bacteria using a novel mass-tagged probe-mediated cascaded signal amplification strategy. Chem Sci. 2022;13(43):12799-12807. doi:10.1039/d2sc01530g.

8.Li X, Sun B, Zhu J, Qian M, Chen Y*. Construction of a Mass-Tagged Oligo Probe Set for Revealing Protein Ratiometric Relationship Associated with EGFR-HER2 Heterodimerization in Living Cells. Anal Chem. 2022;94(25):8838-8846. doi:10.1021/acs.analchem.1c04989.

9.Liu L, Kuang Y, Wang Z, Chen, Y*. A photocleavable peptide-tagged mass probe for chemical mapping of epidermal growth factor receptor 2 (HER2) in human cancer cells. Chem Sci. 2020;11(41):11298-11306. doi:10.1039/d0sc04481d.

10.Hu J, Wang T, Zhang W, Hao H, Yu Q, Gao H, Zhang N, Chen Y*, Xia X, Chen H, Xu J*. Dissecting the Flash Chemistry of Electrogenerated Reactive Intermediates by Microdroplet Fusion Mass Spectrometry. Angew Chem Int Ed Engl. 2021;60(34):18494-18498. doi:10.1002/anie.202106945.

11.Hu Y, Wang Z, Liu L, Zhu J, Zhang D, Xu M, Zhang Y, Xu F, Chen Y*. Mass spectrometry-based chemical mapping and profiling toward molecular understanding of diseases in precision medicine. Chem Sci. 2021;12(23):7993-8009. doi:10.1039/d1sc00271f.

12.Sun B, Xu F, Zhang Y, Hu Y, Chen Y*. Dual-Probe Approach for Mass Spectrometric Quantification of MUC1-Specific Terminal Gal/GalNAc In Situ. Anal Chem. 2020;92(12):8340-8349. doi:10.1021/acs.analchem.0c00807.

13.Kuang Y, Liu L, Wang Z, Chen Y. A photocleavable and mass spectrometric DNA-peptide probe enables fast and specific enzyme-free detection of microRNA. Talanta. 2020;211:120726. doi:10.1016/j.talanta.2020.120726.

14.Li L, Zhang Z, Chen Y, Xu Q, Zhang J, Chen Z*, Chen Y*, Zhu J*. Sustainable and Self-Enhanced Electrochemiluminescent Ternary Suprastructures Derived from CsPbBr3 Perovskite Quantum Dots. Advanced Functional Materials, 2019;29:1902533. doi.org/10.1002/adfm.201902533.

15.Wang Y, Xu F, Xiao K, Chen Y*, Tian Z*. Site- and structure-specific characterization of N-glycoprotein markers of MCF-7 cancer stem cells using isotopic-labelling quantitative N-glycoproteomics. Chem Commun (Camb). 2019;55(55):7934‐7937.

16.Kuang Y, Cao J, Xu F, Chen Y*. Duplex-Specific Nuclease-Mediated Amplification Strategy for Mass Spectrometry Quantification of MiRNA-200c in Breast Cancer Stem Cells. Anal Chem. 2019;91(14):8820‐8826.

17.Liu L, Kuang Y, Yang H, Chen Y*. An amplification strategy using DNA-Peptide dendrimer probe and mass spectrometry for sensitive MicroRNA detection in breast cancer. Anal Chim Acta. 2019;1069:73‐81.