报告题目：一种基于完整细胞的药物筛选策略
报告人： 王伟 教授 南京大学
报告时间：5月8日上午10：30
报告地点：药学院310室
报告摘要：临床前药物筛选准确率的提高有助于降低后续研发过程中的损耗率，降低药物研发成本。待选药物分子与疾病相关蛋白受体之间的结合动力学常数是高通量药物筛选最重要的标准之一。传统“基于纯化蛋白”的药物筛选需要分离和纯化蛋白受体，这一过程存在诸多问题。近年来发展的“基于完整细胞”的药物筛选策略着眼于测定待选药物分子与细胞膜蛋白药物受体之间的原位结合动力学常数，并以此为依据进行药物筛选，有望有效提高筛选准确率。
报告人的三篇代表论文。
1) Wei Wang, Yunze Yang, Shaopeng Wang, Vinay J Nagaraj, Qiang Liu, Jie Wu and Nongjian Tao*, Label-free measuring and mapping of binding kinetics of membrane proteins in single living cells, Nature Chemistry, 2012, 4, 846-853.
2) Wei Wang, Kyle Foley, Xiaonan Shan, Shaopeng Wang, Seron Eaton, Vinay J. Nagaraj, Peter Wiktor, Urmez Patel, Nongjian Tao*, Single cells and intracellular processes studied by a plasmonic-based electrochemical impedance microscopy, Nature Chemistry, 2011, 3, 249-255.
3) Wei Wang*, Nongjian Tao, Detection, Counting and Imaging of Single Nanoparticles, Analytical Chemistry, 2014, 86, 2-14.
2) Wei Wang, Kyle Foley, Xiaonan Shan, Shaopeng Wang, Seron Eaton, Vinay J. Nagaraj, Peter Wiktor, Urmez Patel, Nongjian Tao*, Single cells and intracellular processes studied by a plasmonic-based electrochemical impedance microscopy, Nature Chemistry, 2011, 3, 249-255.
3) Wei Wang*, Nongjian Tao, Detection, Counting and Imaging of Single Nanoparticles, Analytical Chemistry, 2014, 86, 2-14.
