• 都述虎
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  • 发布时间: 2017-04-28 访问次数: 3372
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    都述虎,男,博士,教授,药物分析学系主任,博士生导师,江苏省“六大人才高峰”入选者。
    社会兼职:国家自然科学基金评审专家,国家和江苏省药品审评专家,江苏省科技成果转化项目(生物医药)评审专家,江苏省科技咨询专家,南京医科大学第一届校务委员会委员,南京医科大学学报编委,Biosens. Bioelectron., J. Chromatogr. A, Analyst, Anal. Chim. Acta, Food Chem., RSC Advances 和Talanta等国际期刊审稿人。
    主要研究方向:表面增强拉曼光谱和分子印记技术在现代药物分析中应用研究。
    主要研究成果:近10年来,主要开展分子印记和拉曼光谱技术研究,并成功地应用于天然产物/中药活性成分、农药及药物残留等复杂样品分离与分析;并在Anal. Chem.,  J. Nat. Prod., Biosens. Bioelectron., J. Chromatogr. A,  Analyst和Anal. Chim. Acta等重要期刊发表论文20余篇,授权发明专利3项。先后主持过国家自然科学基金项目3项、国家863 计划项目1项、高等学校博士学科点专项科研基金1项、江苏省“六大人才高峰”项目1项,获江苏中医药科学技术奖二等奖1次。
    学历与研究工作简历
    1983.9-1987.7    安徽中医药大学,药学专业,获理学学士学位
    1997.9-2001.7    中国药科大学,药物分析专业,获理学硕士学位
    2001.9-2004.6    中国药科大学,药物分析专业,获理学博士学位
    1987.7-2004.10   安徽省医学科学研究院药物化学研究室助理研究员、副研究
    员、研究员
    2004.11-2015.2   南京医科大学药学院药学系教授
    2015.3-2016.3    国家食品药品监督管理总局药品审评中心挂职
    2016.4-至今     南京医科大学药学院药物分析学系教授
    承担主要研究课题情况
    2013.1-2016.12  SERS活性的芯-壳型分子印记传感器对青霉素类药物中过敏原的快速检测(21275075,国家自然科学基金委员会资助,主持人)
    2012.1-2014.12 新型分离介质多重分子印记材料设计合成及其在中药药效物质的富集提取中的应用(20113234110001, 2011年度高等学校博士学科点专项科研基金资助, 主持人)
    2011.1-2013.12 荧光信号分子印记聚合物对食品中氮杂环类有害物残留的检测(21075066,国家自然科学基金委员会资助,主持人)
    2008.1-2010.11 高选择性分离富集材料纳米硅胶表面分子印记聚合物的制备及其在重要的有机磷、磺酰脲类农药残留检测中应用(2008AA10Z421,国家863计划资助,主持人)
    2008.1-2010.12 芯-壳结构复合纳米分子印记硅胶的制备及其在葛根异黄酮分离中的应用(07-C-009,江苏省“六大人才高峰”资助,主持人)
    2007.1-2007.12 分子印记纳米硅胶设计合成及其对天然活性甾体皂苷的高选择性分离(30672532,国家自然科学基金委员会资助,主持人)
    发表SCI论文情况
    [1] Yang Jin†, Junting Fan†, Xiaoling Gu, Liying Zhang, Jing Han, Shuhu Du*,and Aixia Zhang*. Neuroprotective activity of cerebrosides from Typhonium giganteum by regulating caspase-3 and Bax/Bcl-2 signaling pathways in PC12 cells. Journal of Natural Products, 2017, DOI 10.1021/acs.jnatprod.6b00954
    [2] Qing Zhang∗, Haoyu Zhao, Dong Li, Liping Liu, Shuhu Du∗.A surface-grafted ligand functionalization strategy for coordinatebinding of doxorubicin at surface of PEGylated mesoporous silicananoparticles: Toward pH-responsive drug delivery. Colloids and Surfaces B: Biointerfaces, 2017, 149 : 138–145
    [3] Xiaoyan Huang†, Yujie Zhou†, Cui Liu, Ruilong Zhang, Liying Zhang, Shuhu Du*, Bianhua Liu, Ming-Yong Han, Zhongping Zhang*. A single dual-emissive nanofluorophore test paper for highly sensitive colorimetry-based quantification of blood glucose. Biosensors and Bioelectronics, 2016, 86 : 530–535
    [4] Yujie Zhou†, Xiaoyan Huang†, Cui Liu, Ruilong Zhang, Xiaoling Gu, Guijian Guan, Changlong Jiang, Liying Zhang, Shuhu Du*, Bianhua Liu, Ming-Yong Han, Zhongping Zhang*. Color-multiplexing-based fluorescent test paper: dosage-sensitive visualization of arsenic(III) with discernable scale as low as 5 ppb. Analytical Chemistry, 2016, 88 (12) : 6105–6109
    [5] Liying Zhang†, Yang Jin†, Xiaoyan Huang, Yujie Zhou, Shuhu Du,* Zhongping Zhang. Ligand replacement approach to Raman-responded molecularly imprinted monolayer for rapid determination of penicilloic acid in penicillin. Analytical Chemistry, 2015, 87 (23) : 11763–11770
    [6] Meihui Qi, Xiaoyan Huang, Yujie Zhou, Liying Zhang, Yang Jin, Yan Peng, Huijun Jiang, Shuhu Du*. Label-free surface-enhanced Raman scattering strategy for rapid detection of penicilloic acid in milk products. Food Chemistry, 2016, 197(Part A): 723–729
    [7] Hui Mao, Meihui Qi, Yujie Zhou , Xiaoyan Huang , Liying Zhang , Yang Jin , Yan Peng, Shuhu Du*. Discrimination of sibutramine and its analogues based on surface-enhanced Raman spectroscopy and chemometrics: toward rapid detection of synthetic anorexic drug in natural slimming product. RSC Advances, 2015, 5(8): 5886–5894
    [8] Guangmei Han, Renyong Liu, Ming-Yong Han, Changlong Jiang, Jianping Wang, Shuhu Du, Bianhua Liu,* and Zhongping Zhang. Label-Free Surface-Enhanced Raman Scattering Imaging to Monitor the Metabolism of Antitumor Drug 6‑Mercaptopurine in Living Cells. Analytical Chemistry, 2014, 86 (23):11503–11507
    [9] Peng Wang†, Aixia Zhang†, Yang Jin, Qing Zhang, Liying Zhang, Yan Peng, Shuhu Du*. Molecularly imprinted layer-coated hollow polysaccharide microcapsules toward gatecontrolled release of water-soluble drugs. RSC Advances, 2014, 4 (50): 26063-26073
    [10] Lei Zheng, Hui Mao, Liying Zhang, Yang Jin, Yujie Zhou, Yan Peng, Shuhu Du*. Aminopyrine Raman spectral features characterised by experimental and theoretical methods: Toward rapid SERS detection of synthetic antipyretic-analgesic drug in traditional Chinese medicine. Analytial Methods, 2014, 6(15):5925–5933
    [11] Qing Zhang, Liying Zhang, Peng Wang, Shuhu Du*. Coordinate bonding strategy for molecularly imprinted hydrogels: Toward pH-responsive doxorubicin delivery. Journal of Pharmaceutical Sciences, 2014, 103(2):643-651
    [12] Liying Zhang, Yang Jin, Hui Mao, Lei Zheng, Jiawei Zhao, Yan Peng, Shuhu Du*, Zhongping Zhang*. Structure-selective hot-spot Raman enhancement for direct identification and detection of trace penicilloic acid allergen in penicillin. Biosensors and Bioelectronics, 2014, 58:165–171
    [13] Jiawei Zhao†, Li Nie†, Liying Zhang, Yang Jin, Yan Peng, Shuhu Du*, Nan Jiang*. Molecularly imprinted layer-coated silica nanoparticle sensors with guest-induced fluorescence enhancement: theoretical prediction and experimental observation. Analytial Methods, 2013, 5(12):3009-3015
    [14] Jing Luo , Liying Zhang , Danjun Chen , Peng Wang , Jiawei Zhao, Yan Peng , Shuhu Du*, Zhongping Zhang*. Molecularly imprinted layer-coated monodisperse spherical silica microparticles toward affinity-enrichment of isoflavonoid glycosides from Radix Puerariae. Analyst, 2012, 137 (12):2891-2902
    [15] Danjun Chen, Junting Fan, Peng Wang, Lanying Zhu, Yang Jin, Yan Peng, Shuhu Du*. Isolation, identification and antioxidative capacity of water-soluble phenylpropanoid compounds from Rhodiola crenulata. Food Chemistry, 2012, 134 (4) : 2126-2133
    [16] Ying Xie, Danjun Chen, Jiawei Zhao, Yan Peng, Nan Jiang, Xuemin Zhou, Shuhu Du*, Zhongping Zhang*. An efficient hybrid design to prepare highly dense imprinted layer-coated silica particles for selective uptake of trace metsulfuron-methyl from complicated matrices. RSC Advances, 2012,  2(1) : 273-283
    [17] Shu Wang, Yun Li, Meijuan Ding, Xiaoli Wu, Jinhui Xu, Ruoyu Wang, Tingting Wen, Wenyu Huang, Ping Zhou, Kunfang Ma, Xuemin Zhou∗, Shuhu Du∗. Self-assembly molecularly imprinted polymers of 17β-estradiol on the surface of magnetic nanoparticles for selective separation and detection of estrogenic hormones in feeds. Journal of Chromatography B, 2011, 879 (25): 2595-2600
    [18] Qing Lu, Xuemei Chen, Li Nie, Jing Luo, Huijun Jiang, Lina Chen, Qin Hu, Shuhu Du*, Zhongping Zhang. Tuning of the vinyl groups’ spacing at surface of modified silica in preparation of high density imprinted layer-coated silica nanoparticles: A dispersive solid-phase extraction materials for chlorpyrifos. Talanta, 2010, 81(3) : 959–966
    [19] Yan Peng , Ying Xie , Jing Luo , Li Nie , Yun Chen, Lina Chen , Shuhu Du*, Zhongping Zhang*. Molecularly imprinted polymer layer-coated silica nanoparticles toward dispersive solid-phase extraction of trace sulfonylurea herbicides from soil and crop samples. Analytica Chimica Acta, 2010 , 674(2) : 190–200
    [20] Chunxiao Zhai, Qing Lu, Xuemei Chen, Yan Peng, Lina Chen, Shuhu Du*. Molecularly imprinted layer-coated silica nanoparticles toward highly selective separation of active diosgenin from Dioscorea nipponica Makino. Journal of Chromatography A, 2009, 1216 (12) : 2254–2262
    [21] Yan Peng, Jing Luo, Qing Lu, Xuemei Chen, Ying Xie, Lina Chen,Wei Yang, Shuhu Du*. HPLC analysis, semi-preparative HPLC preparation and identification of three impurities in salidroside bulk drug.  Journal of Pharmaceutical and Biomedical Analysis, 2009, 49(3) : 828–832
    专利授权情况
    [1] 都述虎,彭艳,罗晶,陆庆,陈立娜,李飞,杨伟. 红景天苷及其杂质的分离方法和红景天苷及其杂质的RP-HPLC分析法,2011.1,中国,200810196164.0
    [2] 都述虎,彭艳,陆庆,罗晶,谢颖,陈雪梅,陈丹君,聂力,陈立娜,李飞.  磺酰脲类除草剂纳米硅胶表面分子印记聚合物的制备方法,2011.12,中国,200910234239.4
    [3] 都述虎,陆庆,彭艳,陈雪梅,谢颖,罗晶,聂力,陈丹君,陈立娜,胡琴.  有机磷类杀虫剂纳米硅胶表面分子印记聚合物的制备方法,2012.7,中国,200910234240.7
    教材编写情况
    参编《天然药物化学》(案例版第2版 2017 科学出版社)教材1部。

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