• 傅俊杰
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  • 发布时间: 2017-05-05 访问次数: 11
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    傅俊杰,男,1986年出生,博士,南京医科大学药物化学系副教授。
    电话:025-86868480
    Email:jfu@njmu.edu.cn
    实验室:至诚楼北楼535
    2013年于中国药科大学获得药物化学博士学位,导师是一氧化氮(NO)供体领域专家张奕华教授和我国著名药物化学家彭司勋院士。2013–2015年在美国佛罗里达大学进行博士后研究。2015年12月进入南京医科大学药物化学系工作,负责有机化学、药物设计等课程。主要研究方向是靶向性抗肿瘤药物和基于气体信使分子的药物设计。目前主持国家自然科学基金青年项目一项、江苏省自然科学基金青年项目一项等。担任《药学研究》编委,Eur J Med Chem、Tetrahedron、Tetrahedron Lett、Molecules等杂志审稿人。
    主要学术论文
    1.Han, J.; Wang, Y.; Meng, Q.; Li, G.; Huang, F.; Wu, S.; Fei, Y.; Zhou, F.; Fu, J.* Design, synthesis and biological evaluation of PEGylated Xenopus glucagon-like peptide-1 derivatives as long-acting hypoglycemic agents. Eur. J. Med. Chem. 2017, 132, 81-89.
    2.Zhu, X.; Fu, J. (co-first author); Tang, Y.; Gao, Y.; Zhang, S.; Guo, Q. Design and synthesis of novel 4'-demethyl-4-deoxypodophyllotoxin derivatives as potential anticancer agents. Bioorg. Med. Chem. Lett. 2016, 26, 1360-1364.
    3.Liu, J.; Fu, J. (co-first author); Li, W.; Zou, Y.; Huang, Z.; Xu, J.; Peng, S.; Zhang, Y. Utilization of the inherent nucleophile for regioselective O-acylation of polyphenols via an intermolecular cooperative transesterification. Tetrahedron 2016, 72, 4103-4110.
    4.Fu, J.; Xia, A.; Qi, X. Identification of novel peptoid agonists of fibroblast growth factor receptors using microarray-based screening. MedChemComm 2016, 7, 1183-1189.
    5.Cui, X.; Meng, Q.; Chu, Y.; Gu, X.; Tang, Y.; Zhou, F.; Fei, Y.; Fu, J.*; Han, J. Glucagon-like peptide-1 loaded phospholipid micelles for the treatment of type 2 diabetes: improved pharmacokinetic behaviours and prolonged glucose-lowering effects. RSC Advances 2016, 6, 94408-94416.
    6.Fu, J.; Zou, Y.; Huang, Z.; Yan, C.; Zhou, Q.; Zhang, H.; Lai, Y.; Peng, S.; Zhang, Y. Identification of nitric oxide-releasing derivatives of oleanolic acid as potential anti-colon cancer agents. RSC Advances 2015, 5, 19445-19454.
    7.Fu, J.; Khaybullin, R.; Zhang, Y.; Xia, A.; Qi, X. Gene expression profiling leads to discovery of correlation of matrix metalloproteinase 11 and heparanase 2 in breast cancer progression. BMC Cancer 2015, 15, 473.
    8.Fu, J.; Lee, T.; Qi, X. The identification of high-affinity G protein-coupled receptor ligands from large combinatorial libraries using multicolor quantum dot-labeled cell-based screening. Future Med Chem 2014, 6, 809-823.
    9.Fu, J.; Liu, L.; Huang, Z.; Lai, Y.; Ji, H.; Peng, S.; Tian, J.; Zhang, Y. Hybrid molecule from O2-(2,4-dinitrophenyl)diazeniumdiolate and oleanolic acid: A glutathione S-transferase π-activated nitric oxide prodrug with selective anti-human hepatocellular carcinoma activity and improved stability. J. Med. Chem. 2013, 56, 4641-4655.
    10.Liu, L.; Fu, J. (co-first author); Li, T.; Cui, R.; Ling, J.; Yu, X.; Ji, H.; Zhang, Y. NG, a novel PABA/NO-based oleanolic acid derivative, induces human hepatoma cell apoptosis via a ROS/MAPK-dependent mitochondrial pathway. Eur. J. Pharmacol. 2012, 691, 61-68.
    11.Huang, Z.; Fu, J. (co-first author); Liu, L.; Sun, Y.; Lai, Y.; Ji, H.; Knaus, E. E.; Tian, J.; Zhang, Y. Glycosylated diazeniumdiolate-based oleanolic acid derivatives: synthesis, in vitro and in vivo biological evaluation as anti-human hepatocellular carcinoma agents. Org. Biomol. Chem. 2012, 10, 3882-3891.
    主持课题
    1.国家自然科学基金青年基金:靶向性一氧化氮供体型铁螯合剂的设计、合成和抗肿瘤活性研究
    2.江苏省自然科学基金青年基金:具有抗肿瘤活性的靶向性一氧化氮供体型铁螯合剂研究
    3.南京医科大学引进人才科研启动基金:靶向性一氧化氮供体型铁螯合剂的设计、合成和抗肿瘤活性研究
    4.江苏省高校自然科学研究面上项目
    5.中国药科大学天然药物活性组分与药效国家重点实验室开放课题

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