• 吴斌
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  • 发布时间: 2017-05-05 访问次数: 10
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    吴斌,药学博士,南京医科大学药学院药物化学系副教授,硕士生导师。
    研究方向
    1. 抗缺血性脑卒中神经保护剂研究;
    2. 药物晶体的培养与晶体结构研究;
    3. 新型孪药的发现与生物活性研究。
    科研项目
    1. 国家自然科学基金面上项目,81371451,具有NMDA受体NR2B选择性拮抗活性的依达拉奉衍生物的发现,2014/01-2017/12,70万元,在研,主持;
    2. 江苏省自然科学基金面上项目,BK20131390,新型依达拉奉-NMDA受体NR2B选择性拮抗剂孪药的设计、合成及生物活性研究,2013/07-2016/06,10万元,已结题,主持;
    3. 江苏省自然科学基金面上项目,BK2010538,新型多重作用机制抗脑卒中神经保护剂的发现,2010/06-2012/12,10万元,已结题,主持;
    4. 国家自然科学基金面上项目,20777038,分子印迹纳米硅胶搅拌棒涂层的研制及其在酚类环境激素分析中的应用,2008/01-2010/12,30万元,已结题,参加。
    研究成果
    (1) Zhong Yan, Xu Yi, Zhang Aixia, Li Xiaofeng, Xu Zhaoying, Li Ping, Wu Bin*, Synthesis and biological evaluation of aryloxyacetamide derivatives as neuroprotective agents, Bioorg. Med. Chem. Lett., 2016, 26(10), 2526-2530
    (2) Xu Zhaoying, Zhong Yan, Liu Yalin, Xu Yi, Li Ping, Wu Bin*, Synthesis, crystal structure and neuroprotective activity of (E)-1-(4-(4-chlorobenzyl)piperazin-1-yl)-3- (benzo[d][1,3]dioxol-5-yl)prop-2-en-1-one, Chinese J. Struct. Chem., 2016, 35(9), 1348-1354
    (3) Zhong Yan, Liu Ya-lin, Xu Zhao-ying, Xu Yi, Li Ping, Wu Bin*, Synthesis, Crystal Structure and Anti-ischemic Activity of (E)-1-(4-(Bis(4-methoxyphenyl)- methyl)piperazin-1-yl)-3-(4-acetoxy-3-methoxyphenyl)prop-2-en-1-one, Chinese J Struct. Chem., 2015, 34(5), 681-687
    (4) Yan Zhong, Zhaoying Xu, Yao Wang, Yi Xu, Ping Li, BinWu*, Synthesis, Crystal Structure and Anti-ischaemic Activity of (E)-1-{4-[Bis(4-methoxyphenyl)methyl]- piperazin-1-yl}-3-(4-chlorophenyl)-prop-2-en-1-one, S. Afr. J Chem., 2014, 67, 214-217
    (5) Zhong Yan, Wang Yao, Wang Jing, Xu Yi, Li Ping, Wu Bin*, Synthesis, Crystal Structure and Neuroprotection of Methyl 2-((4-(2-(2-Methylphenoxy)acetyl)-
    piperazin-1-yl)-methyl)benzoate, Chinese J Struct. Chem., 2014, 33(7), 1096-1101
    (6) Zhaohui Dai, Yan Zhong, BinWu*, 1-[Bis(4-fluorophenyl)methyl]-4-[2-(2- methylphenoxy)ethyl]piperazine, Acta Cryst. Section E, 2012, E68(4), o1077-o1077
    (7) Yan Zhong, Jing Wang, Yao Wang, BinWu*, Preparation and evaluation of liposome-encapsulated codrug LMX, Int. J Pharma., 2012, 438(1-2), 240-248
    (8)Yan Zhong, Zhaohui Dai, Yi Xu, Yanbo Teng, BinWu*, Synthesis, stability and pharmacological evaluation of a novel codrug consisting of lamivudine and ursolic acid, Eur. J Pharm. Sci., 2012, 45(1), 110-115
    (9) Yanbo Teng, Zhaohui Dai, BinWu*, (E)-1-{4-[Bis(4-methoxyphenyl)-methyl]- piperazin-1-yl}-3-(4-fluorophenyl)prop-2-en-1-one, Acta Cryst. Section E, 2011, E67(3), o697-o697
    (10) BinWu*, Li Zhou, Huihui Cai, Synthesis and neuroprotective properties of novel cinnamide derivative, Chinese Chem. Lett., 2008, 19(10), 1163-1166
    (11) 吴斌,王晶,王垚,许逸,李萍,张晓平,芳基取代的哌嗪羰基衍生物及其制备方法和应用,2015. 09. 02,中国,ZL201310681575.X
    (12) 吴斌,滕言波,戴兆慧,许逸,李萍,张晓平,取代二苯甲基哌嗪类衍生物及其制备方法和应用,2014. 11. 05,中国,ZL201210442172.5
    (13) 吴斌,戴兆慧,王晶,许逸,李萍,张晓平,取代芳氧乙基哌嗪类衍生物及其制备方法和应用,2014. 11. 05,中国,ZL201210440778.5
    (14) 吴斌,朱东亚,李飞,一类取代的肉桂酰胺衍生物及其作为神经保护剂的应用,2012. 09. 05,中国,ZL200810020419.8
    联系方式:wubin@njmu.edu.cn

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