陈宏山

发布时间：2017-04-28浏览次数：5665

陈宏山，博士，教授，博士生导师。药学院江苏省心脑血管药物重点实验室，常务副主任；转化医学研究院江苏省医学大数据中心，主任；第二附属医院心血管中心，教授；江苏省心血管病转化医学协同创新，PI。2007年复旦大学医学院心血管生物工程制药专业博士毕业。2008年至2016年，在美国爱因斯坦医学院从事细胞衰老与疾病表观遗传学及分子药理学研究。近年来以第一作者或通讯作者在Molecular Cell、 Nature Structural and Molecular Biology 、Nature Protocols、Oncogene 、Cancer Research等国际知名杂志上发表多篇文章。2016年底作为高层次引进人才受聘于南京医科大学药学院江苏省心脑血管药物重点实验室，承担课题多项。

E-mail：hongshanchen@njmu.edu.cn

研究方向：

衰老相关性疾病(心血管疾病及转移性肿瘤)的表观遗传学机制及药物开发

核心技术：

1.本课题组具有专业生物信息学分析团队，熟练掌握大规模基因组学二代测序分析，医学数据库的深度挖掘，高通量大数据可视化图形处理与分析。

2.细胞分子生物学，表观遗传学常规及前沿技术。

3.整体疾病动物模型(心血管疾病与转移性肿瘤)的建立和实验评价。

4.新型药物药理学研究和药效学评价。

承担课题：

  1. 南京医科大学高层次人才引进基金，2017年1月-2021年12月，主持

  2. 国家自然科学基金重大研究计划培育项目 (No. 91649125)，PARP-1调控衰老相关分泌表型（SASP）在动脉粥样硬化中的作用研究，2017年1月-2019年12月，主持。

  3. 国家自然科学基金面上项目 (No. 31771334)，SHARPIN蛋白通过组蛋白甲基化酶PRMT5调控细胞慢性炎症网络分子基因表达的机制研究，2018年1月-2021年12月，主持

  4. 江苏省特聘医学专家项目基金，2018年1月-2020年12月，主持

  5. 南京医科大学高水平创新团队(培育)基金，2018年1月-2020年12月，主持

代表性论文(*通讯作者)：

  1. Hongshan Chen, Penelope D. Ruiz, Wendy M. McKimpson, Leonid Novikov, Richard N. Kitsis and Matthew J. Gamble*. MacroH2A1 and ATM play opposing roles in paracrine senescence and the senescence-associated secretory phenotype. Molecular Cell. Sep 3;59(5):719-31, 2015.

    (Highlighted by Molecular Cell, Cancer Discovery)

  2. Hongshan Chen, Penelope D. Ruiz, Leonid Novikov, Alyssa D. Casill, Jong Woo Park, and Matthew J. Gamble*. MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylation. Nature Structural and Molecular Biology. Nov; 21(11):981-989, 2014.

    (Highlighted by Nature Structural and Molecular Biology)

  3. Sucrose preference test for measurement of stress-induced anhedonia in mice. Meng-Ying Liu, Chun-Yu Yin, Li-Juan Zhu, Xian-Hui Zhu, Chun-Xia Luo, Hongshan Chen*, Dong-Ya Zhu*, & Qi-Gang Zhou*. Nature Protocols. Accepted. February 6, 2018.

  4. Hongshan Chen*, Benjamin Lorton, Varun Gupta, David Shechter*.A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression. Oncogene.Jan;19;36(3):373-386, 2017.

    (Highlighted by Einstein homepage news, Epibeat)

  5. Songtao Yu, Xiaojiao Wang, Peiliang Geng, Xudong Tang, Lisha Xiang, Xin Lu, Jianjun Li, Zhihua Ruan, Jianfang Chen, Ganfeng Xie, Zhe Wang, Juanjuan Ou, Yuan Peng, Xi Luo, Xuan Zhang, Yan Dong, Xueli Pang, Hongming Miao, Hongshan Chen*,Houjie Liang*. Melatonin regulates PARP-1 to control the senescence-associated secretory phenotype (SASP) in human fetal lung fibroblast cells. Journal of Pineal Research. 2017 Aug; 63(1). doi: 10.1111/jpi.12405.

  6. Yun Mai, J. Jessica Yu, Boris Bartholdy, Zijun Y. Xu-Monette, Esther E. Knapp, Fei Yuan, Hongshan Chen, B. Belinda Ding, Zhuhua Yao, Bhaskar Das, Yiyu Zou, Ken He Young, Samir Parekh and B. Hilda Ye*. An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL. Blood. 2016 Dec 15;128(24):2797-2807.

  7. HaowenQiao, QingCao, YuchengFu, WeiGuan, FangyunCheng, JuanjuanWu, XinJia, HongshanChen, Yajun Zhou*. Sex-determining region Y-box 9 acts downstream of NADPH oxidase to influence the effect of leptin on PPARgamma1 expression in hepatic stellate cells. BBA - Molecular Basis of Disease. 2016 Nov; 1862 (11):2186-2196.

  8. Kristine M. Hussey, Hongshan Chen, Christine Yanga, Eugene Parka, Nasun Hah , Hediye Erdjument-Bromage, Paul Tempst, Matthew J. Gamble and W. Lee Kraus*. The histone variant MacroH2A1 regulates target gene expression in part by recruiting the transcriptional coregulator PELP1. Mol Cell Biol. 34(13):2437-49, 2014. (Equal Contribution).

  9. Wei-lin Wang, Lissa C Anderson, Joshua J Nicklay, Hongshan Chen, Matthew J Gamble, Jeffrey Shabanowitz, Donald F Hunt and David Shechter*. Phosphorylation and arginine methylation mark histone H2A prior to deposition during Xenopus laevis development. Sep 6;7:22. Epigenetics & Chromatin. 2014 Sep 6;7:22.

  10. J. Jessica Yu,Yun Mai,Enguang Bi, Hongshan Chen,B. Belinda Ding,Bhaskar Das,Samir Parekh,Yiyu Zou, and B. Hilda Ye*. STAT3 inhibition overcomes CHOP-resistance in the activated B-cell subtype of DLBCL by a ROS-dependent mechanism. Cancer Research. April 15, 2013 73; 2913 (8 Supplement).

  11. Xuguang Zhai, Kunfeng Yan, Jiye Fan, Minghui Niu, Qian Zhou, Yan Zhou, Hongshan Chen and Yajun Zhoup*.. The β-catenin pathway contributes to the effects of leptin on SREBP-1c expression in rat hepatic stellate cells and liver fibrosis.Br J Pharmacol.169(1):197-212, 2013.

  12. B. Belinda Ding, Enguang Bi, Hongshan Chen, J. Jessica Yu, and B. Hilda Ye*. IL-21 and CD40L synergistically synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells. J. Immunol, 190(4):1827-36, 2013.

  13. Leonid Novikov, Jong Woo Park, Hongshan Chen, Hadassa Klerman, Abubakar S. Jalloh, and Matthew J. Gamble*. QKI-mediated alternative splicing of the histone variant macroH2A1 regulates cancer cell proliferation. Mol. Cell. Biol, 31(20) :4244-55, 2011.

  14. Hongshan Chen, Wei Mo, Yanling Zhang, Huabo Su, Janying Ma, Ruiming Yao, Shaoheng Zhang, Junbo Ge, Houyan Song*. Functional properties of a novel mutant of staphylokinase with platelet-targeted fibrinolysis and antiplatelet aggregation activities. European Journal of Pharmacology, 566:137-144, 2007.

  15. Hongshan Chen, Wei Mo, Huabo Su, Yanling Zhang, Houyan Song*. Characterization of a novel bifunctional mutant of staphylokinase with platelet-targeted fibrinolysis and antiplatelet aggregation activities. BMC Molecular Biology, Oct 7, 2007, 8(1):88.

  16. Zhou Yajun, Chen Hongshan, Sha Baoxi, Yao Dengbing, Shi Jianhua, Ge Xinshun, Yin Li, Cao Yi*. Translocation of Bax in rat hepatocytes cultured with ferric nitrilotriacetate. Life Sciences, 76: 2763–2772, 2005.

  17. Zhu Li, Zhang Ye, Chen Hongshan, Jin Shuyi*. Signal transduction pathway of the protective effects of ginkgolides on chemical hypoxia injury to cortical neurons. Acta Biochim Biophys Sin., 36:163-166, 2004.

  18. Wu xiaomei, Chen Hongshan, Jin shuyi, Zhu li*. Effects of ginkgolides against injury of neurocytes induced by H2O2 and expression of immediate early gene.Chin J Clin Pharmacol Ther, 2003, 8: 401-404.

  19. Chen Hongshan, Wu Xiaomei, Zhu Li, Jin Shuyi*. Effects of ginkgolides against injury of cultured mouse cortical neurons injured by hypoxia and expression of immediate early gene. Chinese J Integrated Chinese and Western Medicine, 15:138-143, 2002.